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Feasibility of quantifying the myocardial blood flow with a shorter acquisition time using O-15 water PET.
https://repo.qst.go.jp/records/47488
https://repo.qst.go.jp/records/474885e138b9c-1e41-4bdd-a44e-1d6f2263372a
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-08-22 | |||||
| タイトル | ||||||
| タイトル | Feasibility of quantifying the myocardial blood flow with a shorter acquisition time using O-15 water PET. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Maruo, Ayaka
× Maruo, Ayaka× Manabe, Osamu× Yoshinaga, Keiichiro× Naya, Masanao× YUuki Tomiyama× N, Oyama-Manabe× Hirata, Kenji× Magota, Keiichi× H, Tsutsui× Katoh, Chietsugu× Tamaki, Nagara× 吉永 恵一郎 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: The quantification of coronary flow reserve（CFR）calculated as the ratio of the myocardial blood flow（MBF）during adenosine triphosphate（ATP）stress to MBF at rest is a useful method for evaluating the functional severity of coronary artery disease（CAD）using 15O-H2O positron emission tomography（PET）. The shorter acquisition time may reduce dyspnea and other side effects of ATP stress and may also reduce the effect of body movements during data acquisition. However, the impact of the shorter data acquisition time on the accuracy of MBF quantification has not been studied. In this retrospective study, we evaluated the accuracy of the MBF and CFR values obtained with shorter scan times using 15O-H2O PET. Methods: Thirty patients suspected of having CAD（22 males, 8 females; age 56.5±8.8 yrs）and 17 healthy controls（17 males; age 27.7±6.2 yrs）underwent PET during rest and PET with ATP stress dynamic 15O-H2O. The MBF was estimated with a one-tissue compartment model analysis. MBF and CFR values were calculated using the first 2-min and 3-min PET data of 15O-H2O as shorter data acquisitions. These data were compared to the standard 6-min PET acquisition data. Results: With the use of the 3-min data, the regions of interest（ROIs）in the left ventricular（LV）chamber and myocardium could be set for all of the subjects. The intraclass correlation coefficients （ICCs）between the 3-min data and 6-min data of the rest MBF, stress MBF and CFR were 0.869, 0.870, and 0.819 in the patients, and 0.912, 0.910, and 0.930 in the controls. The 3-min CFR data showed a significant difference between the patients and controls（2.22±1.02 vs. 4.02±1.50, p＜0.01）, as did the 6-min data（2.19±0.92 vs. 4.16±1.39, p＜0.01）. However, the CFR based on 2-min data did not show a significant difference（1.96±1.66 vs. 2.73±1.03, p=0.088）. Using a receiver operating characteristic（ROC）analysis, we observed that both the 3-min and 6-min CFR data could be used to separate the CAD patients and controls. Conclusions: A 3-min, but not 2-min, scan with 15O-H2O PET can be used for the quantitative evaluation of MBF and CFR. Keywords: 15O-H2O, Myocardial blood flow, Pharmacological stress, Positron emission tomography, Shorter acquisition time Ann Nucl Cardiol 2016；2（1）：0-0 |
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| 書誌情報 |
Annals of Nuclear Cardiology 巻 2, 号 1, 発行日 2016-02 |
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| 出版者 | ||||||
| 出版者 | The Japanese Society of Nuclear Cardiology | |||||
