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A method to visualize transdermal nickel permeation in mouse skin using a nickel allergy patch
https://repo.qst.go.jp/records/47465
https://repo.qst.go.jp/records/47465fd85c1f1-630c-43ed-9727-ac02197cbe13
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-08-10 | |||||
| タイトル | ||||||
| タイトル | A method to visualize transdermal nickel permeation in mouse skin using a nickel allergy patch | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Tomoko, Sugiyama
× Tomoko, Sugiyama× Motohiro, Uo× Takahiro, Wada× Toshio, Hongo× Daisuke, Omagari× Kazuo, Komiyama× Oikawa, Masakazu× Mikio, Kusama× Mori, Yoshiyuki× 及川 将一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Metal patch test is often used in clinical settings when metal-induced contact dermatitis is suspected. However, the transdermal permeation behavior of metal ions from the patch test remains unclear. Current patch tests using high concentrations of metal salt solutions have some side effects, e.g. acute skin reactions to high concentrations of metal salt. To resolve these, estimating metal ion transdermal permeation is wished. In this study, synchrotron radiation X-ray fluorescence (SR-XRF) and micro-focused particle-induced X-ray emission (micro-PIXE) were used to visualize the time-dependent Ni permeation in mouse skin. The cross-sectional diffusion of Ni was visualized in a time-dependent manner. Our results indicate that maximum Ni permeation occurs after 24 h of patch treatment, and the permeated Ni content was high in the epidermis and spread into the dermis beyond the basal layer. This method may be useful to determine the appropriate solution concentration and duration of administration for the patch test. | |||||
| 書誌情報 |
Bio-Medical Materials and Engineering 巻 26, 号 1/2, p. 1-8, 発行日 2015-12 |
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| 出版者 | ||||||
| 出版者 | IOS Press, Inc. | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0959-2989 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3233/BME-15154 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://content.iospress.com/articles/bio-medical-materials-and-engineering/bme1543 | |||||
| 関連名称 | http://content.iospress.com/articles/bio-medical-materials-and-engineering/bme1543 | |||||
