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Biological measures to minimize the risk of radiotherapy-associated second cancer: a research perspective
https://repo.qst.go.jp/records/47436
https://repo.qst.go.jp/records/47436112d7923-f170-45c8-8926-ff274e733b93
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-07-05 | |||||
| タイトル | ||||||
| タイトル | Biological measures to minimize the risk of radiotherapy-associated second cancer: a research perspective | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Imaoka, Tatsuhiko
× Imaoka, Tatsuhiko× Ishii, Nobuyoshi× Kawaguchi, Isao× Homma-Takeda, Shino× Doi, Kazutaka× Daino, Kazuhiro× Nakanishi, Ikuo× Tagami, Keiko× Kokubo, Toshiaki× Morioka, Takamitsu× Hosoki, Ayaka× Takabatake, Masaru× Yoshinaga, Shinji× 今岡 達彦× 石井 伸昌× 川口 勇生× 武田 志乃× 土居 主尚× 臺野 和広× 中西 郁夫× 田上 恵子× 小久保 年章× 森岡 孝満× 細木 彩夏× 高畠 賢× 吉永 信治 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: Second cancers are among the most serious sequelae for cancer survivors who receive radiotherapy. This article aims to review current knowledge regarding how the risk of radiotherapy-associated second cancer can be minimized by biological measures and to discuss relevant research needs. Results: The risk of second cancer can be reduced not only by physical measures to decrease the radiation dose to normal tissues but also by biological means that interfere with the critical determinants of radiation-induced carcinogenesis. Requirements for such biological means include the targeting of tumor types relevant to radiotherapy-associated risk, concrete safety and efficacy evidence and feasibility and minimal invasiveness. Mechanistic insights into the process of radiation carcinogenesis provide rational approaches to minimize the risk. Five mechanism-based strategies are proposed herein based on the current state of knowledge. Epidemiological studies on the joint effects of radiation and lifestyle or other factors can provide evidence for factors that modify radiation-associated risks if deliberately controlled. Conclusions: Mechanistic and epidemiological evidence indicates that it is possible to develop interventional measures to minimize the second cancer risk associated with radiotherapy. Research is needed regarding the critical determinants of radiation-induced carcinogenesis available for intervention and joint effects of radiation and controllable factors. |
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| 書誌情報 |
International Journal of Radiation Biology 巻 92, 号 6, p. 289-301, 発行日 2016-03 |
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| 出版者 | ||||||
| 出版者 | Informa Healthcare | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0955-3002 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3109/09553002.2016.1152413 | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | http://dx.doi.org/10.3109/09553002.2016.1152413 | |||||
| 関連名称 | http://dx.doi.org/10.3109/09553002.2016.1152413 | |||||
