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Washout rate in rat brain irradiated by a (11)C beam after acetazolamide loading using a small single-ring OpenPET prototype.
https://repo.qst.go.jp/records/47433
https://repo.qst.go.jp/records/4743382794dad-cfa6-4f90-8a0d-e99c7c7bd659
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-06-02 | |||||
| タイトル | ||||||
| タイトル | Washout rate in rat brain irradiated by a (11)C beam after acetazolamide loading using a small single-ring OpenPET prototype. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hirano, Yoshiyuki
× Hirano, Yoshiyuki× Takuwa, Hiroyuki× Yoshida, Eiji× Nishikido, Fumihiko× Nakajima, Yasunori× Wakizaka, Hidekatsu× Yamaya, Taiga× 平野 祥之× 田桑 弘之× 吉田 英治× 錦戸 文彦× 中島 靖紀× 脇坂 秀克× 山谷 泰賀 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In dose verification techniques of particle therapies based on in-beam positron emission tomography (PET), the causes of washout of positron emitters by physiological effects should be clarified to correct washout for accurate verification. As well, the quantitative washout rate has a potential usefulness as a diagnostic index which should be explored. Therefore, we measured washout rates of rat brain after vasodilator acetazolamide loading to investigate the possible effects of blood flow on washout. Six rat brains were irradiated by a radioisotope (11)C beam and time activity curves on the whole brains were obtained with a small single-ring OpenPET prototype. Then, washout rates were calculated with the Mizuno model, where two washout rates (k 2m and k 2s ) were assumed, and a two-compartment model including efflux from tissue to blood (k 2) and influx (k 3) and efflux (k 4) between the two tissue compartments. Before the irradiations, we used laser-Doppler flowmetry to confirm that acetazolamide increased cerebral blood flow (CBF) of a rat. We compared means of k 2m , k 2s and k 2, k 3 and k 4 without acetazolamide loading (Rest) and with acetazolamide loading (ACZ). For all k values, ACZ values were lower than Rest values. In other words, though CBF increased, washout rates were decreased. This may be attributed to the implanted (11)C reacting to form (11)CO2. Because acetazolamide increased the concentration of CO2 in brain, suppressed diffusion of (11)CO2 and decomposition of (11)CO2 into ions were prevented. | |||||
| 書誌情報 |
Physics in medicine and biology 巻 61, 号 5, p. 1875-1887, 発行日 2016-02 |
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| 出版者 | ||||||
| 出版者 | IOPscience | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0031-9155 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 26863938 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1088/0031-9155/61/5/1875 | |||||
