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Irradiation induces diverse changes in invasive potential in cancer lines.
https://repo.qst.go.jp/records/47416
https://repo.qst.go.jp/records/474161409fa30-f8bf-49c9-a4d0-9017231bd8bb
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-05-18 | |||||
| タイトル | ||||||
| タイトル | Irradiation induces diverse changes in invasive potential in cancer lines. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Fujita, Mayumi
× Fujita, Mayumi× Yamada, Shigeru× Imai, Takashi× 藤田 真由美× 山田 滋× 今井 高志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Cancer patients without metastasis are generally considered as candidates for curative localized radiation therapy. However, while the benefits of localized radiation have been demonstrated by many clinical studies, recurrences or distant metastases that develop after local treatment remain a major therapeutic challenge. Several in vitro and in vivo studies have reported that irradiation may subsequently alter tumor aggression by reducing or promoting the invasiveness of the remaining cancer cells after radiation, which appears to differ depending on the form of radiation, as well as the investigated cell lines. Cell lines recapitulate cancer heterogeneity based on the characteristics reflected in their genetic abnormalities, and thus can be used as a tool to investigate the genetic basis of cancer aggression. Importantly, molecular insights into this process would allow us to tailor drug treatments for use in combination with local radiation treatment. This review summarizes the diverse responses of cancer cell invasiveness induced by radiation, and discusses the possible molecular pathways and the genetic variations that may affect radiation-altered invasion. | |||||
| 書誌情報 |
Seminars in cancer biology 巻 35, p. 45-52, 発行日 2015-09 |
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| 出版者 | ||||||
| 出版者 | Academic Press | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1044-579X | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 26410035 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.semcancer.2015.09.003 | |||||
