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Chronic Intake of Japanese Sake Mediates Radiation-Induced Metabolic Alterations in Mouse Liver
https://repo.qst.go.jp/records/47386
https://repo.qst.go.jp/records/47386b83524a6-87f2-4585-9198-399e1cea2f05
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-01-19 | |||||
| タイトル | ||||||
| タイトル | Chronic Intake of Japanese Sake Mediates Radiation-Induced Metabolic Alterations in Mouse Liver | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
中島, 徹夫
× 中島, 徹夫× Ｇｕｉｌｌａｕｍｅ, Ｖａｒｅｓ× 王, 冰× 根井, 充× 中島 徹夫× Ｇｕｉｌｌａｕｍｅ Ｖａｒｅｓ× 王 冰× 根井 充 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Sake is a traditional Japanese alcoholic beverage that is gaining popularity worldwide. Although sake is reported to have beneficial health effects, it is not known whether chronic sake consumption modulates health risks due to radiation exposure or other factors. Here, the effects of chronic administration of sake on radiation-induced metabolic alterations in the livers of mice were evaluated. Sake (junmai-shu) was administered daily to female mice (C3H/He) for one month, and the mice were exposed to fractionated doses of X-rays (0.75 Gy/day) for the last four days of the sake administration period. For comparative analysis, a group of mice were administered 15% (v/v) ethanol in water instead of sake. Metabolites in the liver were analyzed by capillary electrophoresis-time-of-flight mass spectrometry one day following the last exposure to radiation. The metabolite profiles of mice chronically administered sake in combination with radiation showed marked changes in purine, pyrimi- dine, and glutathione (GSH) metabolism, which were only partially altered by radiation or sake administration alone. Notably, the changes in GSH metabolism were not observed in mice treated with radiation following chronic administration of 15% ethanol in water. Changes in several metabolites, including methionine and valine, were induced by radiation alone, but were not detected in the livers of mice who received chronic administration of sake. In addition, the chronic administration of sake increased the level of serum triglycer- ides, although radiation exposure suppressed this increase. Taken together, the present findings suggest that chronic sake consumption promotes GSH metabolism and anti-oxida- tive activities in the liver, and thereby may contribute to minimizing the adverse effects asso- ciated with radiation. | |||||
| 書誌情報 |
PLOS ONE 巻 11, 号 1, p. e0146730-1-e0146730-18, 発行日 2016-01 |
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| 出版者 | ||||||
| 出版者 | Public Library of Science (PLOS) | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | DOI:10.1371/journal.pone.0146730 | |||||
