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Evaluation of semi-quantitative method for quantification of dopamine transporter in human PET study with 18F-FE-PE2I
https://repo.qst.go.jp/records/47348
https://repo.qst.go.jp/records/4734808579681-cb6e-48c7-bf24-65a2368c40b1
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-01-18 | |||||
| タイトル | ||||||
| タイトル | Evaluation of semi-quantitative method for quantification of dopamine transporter in human PET study with 18F-FE-PE2I | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ikoma, Yoko
× Ikoma, Yoko× Sasaki, Takeshi× Kimura, Yasuyuki× Seki, Chie× Okubo, Yoshiro× Suhara, Tetsuya× Ito, Hiroshi× 生駒 洋子× 木村 泰之× 関 千江× 須原 哲也× 伊藤 浩 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objectives: Positron emission tomography (PET) with 18F-FE-PE2I is useful for investigating the function of dopamine transporter, and kinetics of 18F-FE-PE2I could be described by standard two-tissue compartment model (2CM) using plasma input function. In this study, we investigated the feasibility of semi-quantitative methods for estimating binding potential (BPND) and transporter occupancy to shorten the scan period and to reduce the effect of statistical noise on quantitative outcomes using computer simulation and human PET studies with 18F-FE-PE2I. Methods: In the simulations, time-activity curves (TACs) for the putamen with a wide range of BPND were generated. In these TACs, BPNDs were estimated by standardized uptake value ratio (SUVR) using various integration intervals and the simplified reference tissue model (SRTM) with the cerebellum as reference region, and reduction of BPND assuming transporter occupancy by antipsychotics was calculated from BPND obtained from TACs with various BPND values. These estimates were evaluated by comparison with those of 2CM. In human studies with normal volunteers, BPNDs were estimated in the caudate and putamen using SUVR and SRTM with the cerebellar reference region, and compared with BPND by standard 2CM. Results: In the simulations, BPND estimated by SUVR with late time frames and SRTM showed linear correlation with those by 2CM, although the estimates by SUVR were overestimated and affected by the cerebral blood flow as BPND became higher. As for transporter occupancy, SRTM showed higher linearity with 2CM and less effect of statistical noise than the SUVR method. In human studies, BPND by SRTM and SUVR with late time frames showed good correlation with BPND by 2CM. Conclusions: Although SRTM is more reliable than the SUVR method for BPND and occupancy estimation, SUVR using late time frames has the potential to provide practical indices of BPND and occupancy with a shorter scan period. |
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| 書誌情報 |
Annals of Nuclear Medicine 巻 29, 号 8, p. 697-708, 発行日 2015-07 |
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| 出版者 | ||||||
| 出版者 | Springer Japan | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0914-7187 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 26134215 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s12149-015-0993-3 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://link.springer.com/article/10.1007%2Fs12149-015-0993-3 | |||||
| 関連名称 | http://link.springer.com/article/10.1007%2Fs12149-015-0993-3 | |||||
