WEKO3
アイテム
Age dependence of radiation-induced renal cell carcinomas in an Eker rat model
https://repo.qst.go.jp/records/47308
https://repo.qst.go.jp/records/473083a40629d-52b2-4289-905a-72da5dafb270
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-09-17 | |||||
| タイトル | ||||||
| タイトル | Age dependence of radiation-induced renal cell carcinomas in an Eker rat model | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kokubo, Toshiaki
× Kokubo, Toshiaki× Kakinuma, Shizuko× Kobayashi, Toshiyuki× Watanabe, Fumiko× Iritani, Riichirou× Tateno, Kaori× Nishimura, Mayumi× Nishikawa, Tetsu× Hino, Okio× Shimada, Yoshiya× 小久保 年章× 柿沼 志津子× 渡辺 文子× 舘野 香里× 西村 まゆみ× 西川 哲× 樋野 興夫× 島田 義也 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Exposure to carcinogens early in life may contribute to cancer development later in life. The amount of radiation exposure to children during medical procedures has been increasing, so it is important to evaluate the radiation risk of cancer in developing organs. Toward this goal, we assessed the risk of developing renal cell carcinoma using Eker rats as a kidney tumor model. F1 hybrids of male Eker (Tsc2 mutant) and female F344 rats were irradiated with 0.5 or 2 Gy gamma radiation on gestation days 15 and 19, and on postnatal days 5, 20, and 49. At 27 weeks of age, kidneys were examined for proliferative lesions. Preneoplastic lesions such as phenotypically altered tubules increased after postnatal irradiation as a function of age-at-irradiation, and hyperplasia were greatly increased after perinatal and postnatal irradiation. In contrast, development of adenoma and adenocarcinoma were evident in animals irradiated at perinatal ages, being maximal at gestational day 19. The frequency of LOH at the Tsc2 locus was unexpectedly low -0% (0 of 4) for the control, and 17% (6 of 35) for the irradiated group. Irrespective of LOH, the mTOR pathway, which is negatively regulated by the Tsc1/2 complex, was activated in both benign and malignant lesions, as evidenced by phosphorylation of S6 ribosomal protein and 4E-BP1. This suggests that the wild-type Tsc2 allele may be functionally inactivated. In conclusion, the actively growing kidney of (F344 X Eker) F1 rats (Tsc2+/-), at a perinatal age, is at risk for radiation-induced malignant transformation of the renal epithelium associated with mTOR activation. | |||||
| 書誌情報 |
Cancer Science 巻 101, 号 3, p. 616-623, 発行日 2010-02 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1347-9032 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1111/j.1349-7006.2009.01456.x | |||||
