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NCYM promotes calpain-mediated Myc-nick production in human MYCN-amplified neuroblastoma cells
https://repo.qst.go.jp/records/47295
https://repo.qst.go.jp/records/472956c7459be-4725-4d77-b18d-4a8a9617eddb
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-09-15 | |||||
| タイトル | ||||||
| タイトル | NCYM promotes calpain-mediated Myc-nick production in human MYCN-amplified neuroblastoma cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
W, Shoji
× W, Shoji× Suenaga, Y× Kaneko, Y× イスラム, ラフィクル× al., et× イスラム ラフィクル |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | NCYM is a cis-antisense gene of MYCN and is amplified in human neuroblastomas. High NCYM expression is associated with poor prognoses, and the NCYM protein stabilizes MYCN to promote proliferation of neuroblastoma cells. However, the molecular mechanisms of NCYM in the regulation of cell survival have remained poorly characterized. Here we show that NCYM promotes cleavage of MYCN to produce the anti-apoptotic protein, Myc-nick, both in vitro and in vivo. NCYM and Myc-nick were induced at G2/M phase, and NCYM knockdown induced apoptotic cell death accompanied by Myc-nick downregulation. These results reveal a novel function of NCYM as a regulator of Myc-nick production in human neuroblastomas. | |||||
| 書誌情報 |
Biochem Biophys Res Commun. 巻 461, 号 3, p. 501-506, 発行日 2015-06 |
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| 出版者 | ||||||
| 出版者 | ELSEVIRE | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.bbrc.2015.04.050 | |||||
