WEKO3
アイテム
Cellular localization of uranium in the renal proximal tubules during acute renal uranium toxicity
https://repo.qst.go.jp/records/47265
https://repo.qst.go.jp/records/4726507302caa-39a8-483f-a698-1432661acd52
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-08-19 | |||||
| タイトル | ||||||
| タイトル | Cellular localization of uranium in the renal proximal tubules during acute renal uranium toxicity | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Homma-Takeda, Shino
× Homma-Takeda, Shino× Kitahara, Keisuke× Suzuki, Kyoko× J., Blyth Benjamin× Suya, Noriyoshi× Konishi, Teruaki× Terada, Yasuko× Shimada, Yoshiya× 武田 志乃× 鈴木 享子× Ｂｌｙｔｈ Ｂｅｎｊａｍｉｎ× 酢屋 徳啓× 小西 輝昭× 島田 義也 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Renal toxicity is a hallmark of uranium exposure, with uranium accumulating specifically in the S3 segment of the proximal tubules causing tubular damage. Since the distribution, concentration and dynamics of accumulated uranium at the cellular level is not well understood, here, we report on high-resolution quantitative in situ measurements by high energy synchrotron radiation X-ray fluorescence analysis in renal sections from a rat model of uranium-induced acute renal toxicity. At one day after subcutaneous administration of uranium acetate to male Wistar rats at a dose of 0.5 mg uranium/kg body weight, uranium concentration in the S3 segment of the proximal tubules was 64.9 ± 18.2 μg/g, 7-fold higher than the mean renal uranium concentration (9.7 ± 2.4 μg/g). Uranium distributed into the epithelium of the S3 segment of the proximal tubules and highly concentrated uranium (50-fold above mean renal concentration) in micro-regions was found near the nuclei. These uranium levels were maintained out to 8 days post-administration, despite more rapid reductions in mean renal concentration. Two weeks after uranium administration, damaged areas were filled with regenerating tubules and morphological signs of tissue recovery, but areas of high uranium concentration (100-fold above mean renal concentration) were still found in the epithelium of regenerating tubules. These data indicate that site-specific accumulation of uranium in micro-regions of the S3 segment of the proximal tubules and retention of uranium in concentrated areas during recovery are characteristics of uranium behavior in the kidney. | |||||
| 書誌情報 |
Journal of Applied Toxicology 発行日 2015-03 |
|||||
| 出版者 | ||||||
| 出版者 | John Wiley & Sons Ltd | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0260-437X | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 25772475 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1002/jat.3126 | |||||
