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Magnetic resonance imaging of organic contrast agents in mice: capturing the whole-body redox landscape
https://repo.qst.go.jp/records/47254
https://repo.qst.go.jp/records/4725472322345-edda-4bec-9631-a02ea4da2fe2
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-08-14 | |||||
| タイトル | ||||||
| タイトル | Magnetic resonance imaging of organic contrast agents in mice: capturing the whole-body redox landscape | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Davis, Ryan
× Davis, Ryan× Matsumoto, Shingo× Bernardo, Marcelino× Sowers, Anastasia× Matsumoto, Kenichiro× C., Krishna Murali× B., Mitchell James× 松本 謙一郎 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Nitroxides are a class of stable free radicals that have several biomidical applications including radioprotection and noninvasive asessment of tissue redox status. For both of these applicaitons, it is necessary to understand the in vivo biodistribution and reduction of nitroxides. In this study, magnetic resonance imaging was used to compare tissue accumulation (concentration) and reduction of two commonly studied nitroxides: the piperidine nitroxide Tempol and pyrrolidine nitroxide 3-CP. It was found that 3-CP was reduced 3 to 11 times slower (depending on the tissue) than Tempol in vivo and that maximum tissue concentration varies substantially between tissues (0.6-7.2 mM). For a given tissue, the maximum concentration usually did not vary betweeen the two nitroxides. Furthermore, using electron paramagnetic resonance spectroscopy, we showed that the nitroxide reduction rate depends only weakly on cellular pO2 in the oxygen range expected in vivo. These observations, taken with the marked variation in nitorxide reductin rates observed between tissues, suggest that tissue pO2 is not a major determinant of the nitoride reduction rate in vivo. For the purpose of redox imaiging, 3-CP was shown to be an optimal choice based on the achievable concentrations and bioreduction observed in vivo. | |||||
| 書誌情報 |
Free Radical Biology and Medicine 巻 50, 号 3, p. 459-468, 発行日 2011-02 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0891-5849 | |||||
