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Effects of Low-dose Heavy Ions on Embryonic Development in Mice and on Melanocyte Differentiation in the Epidermis and Hair Bulb
https://repo.qst.go.jp/records/47246
https://repo.qst.go.jp/records/472464d9da9dd-896e-44a5-a0e8-aed10384d228
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-08-07 | |||||
| タイトル | ||||||
| タイトル | Effects of Low-dose Heavy Ions on Embryonic Development in Mice and on Melanocyte Differentiation in the Epidermis and Hair Bulb | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hirobe, Tomohisa
× Hirobe, Tomohisa× Eguchi-Kasai, Kiyomi× Sugaya, Kimihiko× Murakami, Masahiro× 廣部 知久× 笠井 清美× 菅谷 公彦× 村上 正弘 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The effects of prenatal low-dose irradiation with heavy ions on embryonic development in mice and on melanocyte differentiation are not well understood. We performed whole-body irradiation of pregnant C57BL/10J mice at embryonic day 9 (E9) with a single dose of gamma-rays, silicon, argon or iron ions. The number of living embryos and embryonic body weight at E18 decreased after exposure to heavy ions at high doses. Malformations such as small eyes and limb anomalies were observed in heavy-ion-treated embryos, but not in gamma-ray-treated embryos. The frequency of abnormally curved tails was increased by exposure to gamma-rays and argon and iron ions even at a dose of 0.1 Gy (P < 0.05). In contrast, a dose-dependent decrease in the number of epidermal melanoblasts/melanocytes and hair bulb melanocytes was observed after 0.1 Gy irradiation with gamma-rays or heavy ions (P < 0.01). The decrease in the number of dorsal hair bulb melanocytes, dorsal and ventral epidermal melanoblasts/melanocytes and ventral hair bulb melanocytes was not necessarily correlated with the linear energy transfer (LET) of the radiation tested. Moreover, the effects of heavy ions were larger on the ventral skin than on the dorsal skin, indicating that the sensitivity of melanocytes to heavy ions differs between the dorsal and ventral skin. Taken together, these results suggest that the effects of the low-dose heavy ions differ between cell types and tissues, and the effects on the prenatal development of mice and melanocyte development are not necessarily greater than those of gamma-rays. | |||||
| 書誌情報 |
Journal of Radiation Research 巻 54, p. 409-418, 発行日 2012-12 |
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| 出版者 | ||||||
| 出版者 | Japan Radiation Research Society | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0449-3060 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | PMC3650742 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1093/jrr/rrs116 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650742/ | |||||
| 関連名称 | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650742/ | |||||
