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Serotonergic neurotransmission in the living human brain: A positron emission tomography study using [11C]DASB and [11C]WAY100635 in young healthy men
https://repo.qst.go.jp/records/47244
https://repo.qst.go.jp/records/47244f5a9c055-efb3-4322-9668-a82fac7003fa
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-08-07 | |||||
| タイトル | ||||||
| タイトル | Serotonergic neurotransmission in the living human brain: A positron emission tomography study using [11C]DASB and [11C]WAY100635 in young healthy men | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Takano, Harumasa
× Takano, Harumasa× Ito, Hiroshi× Takahashi, Hidehiko× Arakawa, Ryosuke× Okumura, Masaki× Kodaka, Fumitoshi× Otsuka, Tatsui× Kato, Motoichiro× Suhara, Tetsuya× 高野 晴成× 伊藤 浩× 高橋 英彦× 荒川 亮介× 奥村 正紀× 小高 文聰× 大塚 達以× 加藤 元一郎× 須原 哲也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The central serotonergic (5-HT) system is closely involved in regulating various mental functions such as mood and emotion. In this system, the serotonin transporter (5-HTT) and the 5-HT1A receptor play important roles in the pathophysiology and treatment of mood and anxiety disorders. However, only a few integrated databases have considered the intraindividual relationship between pre-and postsynaptic serotonergic transmission. In the present study, we constructed a database of 5-HTT and 5-HT1A receptors using positron emission tomography (PET) with [C-11]DASB and [C-11]WAY100635, respectively. Seventeen healthy young men participated in this study. After anatomic standardization of original images, BPND was calculated on a voxel-byvoxel basis using reference tissue methods. The highest binding to 5-HTT was observed in the dorsal raphe nucleus, striatum, and thalamus; moderate binding, in the insula and cingulate cortex; and very low binding, in the cerebral neocortex. In contrast, the highest binding to 5-HT1A receptors was seen in the hippocampal regions, insula, neocortical regions, and dorsal raphe nucleus, and very low binding was found in the thalamus and basal ganglia. These distribution patterns were in agreement with those reported in human postmortem studies and previous PET investigations. In addition, exploratory analysis indicated significant negative correlations between the BPND values with both radiotracers in certain regions of the brain, such as the cingulate, insula, and frontal, temporal and parietal cortices (Pearson's correlation, P < 0.05). These databases facilitate the understanding of the regional distribution of serotonergic neurotransmission function in the living human brain and the pathophysiology of various neuropsychiatric disorders. | |||||
| 書誌情報 |
Synapse 巻 65, 号 7, p. 624-633, 発行日 2011-07 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0887-4476 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 21484882 | |||||
