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Effect of radiolabeled metabolite elimination from the brain on the accuracy of cerebral enzyme activity estimation using positron emission tomography with substrate tracers
https://repo.qst.go.jp/records/47242
https://repo.qst.go.jp/records/4724234a1a178-3e02-496e-ba6f-ca19c0bbf6bd
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-08-07 | |||||
| タイトル | ||||||
| タイトル | Effect of radiolabeled metabolite elimination from the brain on the accuracy of cerebral enzyme activity estimation using positron emission tomography with substrate tracers | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ohya, Tomoyuki
× Ohya, Tomoyuki× Okamura, Toshimitsu× Nagai, Yuji× Fukushi, Kiyoshi× Irie, Toshiaki× Suhara, Tetsuya× Zhang, Ming-Rong× Fukumura, Toshimitsu× Kikuchi, Tatsuya× 大矢 智幸× 岡村 敏充× 永井 裕司× 福士 清× 入江 俊章× 須原 哲也× 張 明栄× 福村 利光× 菊池 達矢 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Cerebral enzyme activity can be quantified using positron emission tomography (PET) in conjunction with a radiolabeled enzyme substrate. We investigated the relationship between the elimination rate (kel) of tracer metabolites from the brain and the precision of target enzyme activity estimation (k3). An initial simulation study indicated that the precision of k3 estimates was highly dependent on kel, and was characterized by several kinetic parameters including the ratio of kel and the efflux rate (k2) of authentic tracer (beta xi kel/k2). The optimal tracer condition for high sensitivity was found to be beta < 0.1. To verify the simulation results, we performed a PET study with a single monkey using two PET tracers, N-[18F]fluoroethylpiperidin-4-ylmethyl acetate ([18F]FEP-4MA) and N-[11C]methylpiperidin-4-yl acetate ([11C]MP4A). Both of these substrate type tracers were developed for measuring cerebral acetylcholinesterase activity. There was good retention of the radioactive metabolite of [11C]MP4A in the brain (kel = 0.0036 +/- 0.0013 min− 1, beta = 0.028), whereas that of [18F]FEP-4MA was eliminated from the brain (kel = 0.012 +/- 0.0010 min− 1, beta = 0.085). A non-linear least square analysis for simultaneous estimation of all parameters showed that the precision of the k3 estimate for [18F]FEP-4MA was as high (7.4%) as that for [11C]MP4A (10%). These results indicate that tracers with metabolites that are eliminated from the brain at a slow rate (beta < 0.1) may be useful for the quantitative measurement of target enzyme activity. | |||||
| 書誌情報 |
NeuroImage 巻 56, 号 3, p. 1105-1110, 発行日 2011-06 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1053-8119 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 21324368 | |||||
