WEKO3
アイテム
Imaging for metabotropic glutamate receptor subtype 1 in rat and monkey brains using PET with [18F]FITM
https://repo.qst.go.jp/records/47239
https://repo.qst.go.jp/records/47239119110ae-3df2-4e95-98fa-e1b0fd50e3dc
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-08-07 | |||||
| タイトル | ||||||
| タイトル | Imaging for metabotropic glutamate receptor subtype 1 in rat and monkey brains using PET with [18F]FITM | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yamasaki, Tomoteru
× Yamasaki, Tomoteru× Fujinaga, Masayuki× Maeda, Jun× Kawamura, Kazunori× Yui, Joji× Hatori, Akiko× Yoshida, Yuichirou× Nagai, Yuji× Tokunaga, Masaki× Higuchi, Makoto× Suhara, Tetsuya× Fukumura, Toshimitsu× Zhang, Ming-Rong× 山崎 友照× 藤永 雅之× 前田 純× 河村 和紀× 由井 譲二× 羽鳥 晶子× 吉田 勇一郎× 永井 裕司× 徳永 正希× 樋口 真人× 須原 哲也× 福村 利光× 張 明栄 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose In this study, we evaluate the utility of 4-[18F]fluoro- N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-Nmethylbenzamide ([18F]FITM) as a positron emission tomography (PET) ligand for imaging of the metabotropic glutamate receptor subtype 1 (mGluR1) in rat and monkey brains. Methods In vivo distribution of [18F]FITM in brains was evaluated by PET scans with or without the mGluR1- selective antagonist (JNJ16259685). Kinetic parameters of monkey PET data were obtained using the two-tissue compartment model with arterial blood sampling. Results In PET studies in rat and monkey brains, the highest uptake of radioactivity was in the cerebellum, followed by moderate uptake in the thalamus, hippocampus and striatum. The lowest uptake of radioactivity was detected in the pons. These uptakes in all brain regions were dramatically decreased by pre-administration of JNJ16259685. In kinetic analysis of monkey PET, the highest volume of distribution (VT) was detected in the cerebellum (VT=11.5). Conclusion [18F]FITM has an excellent profile as a PET ligand for mGluR1 imaging. PET with [18F]FITM may prove useful for determining the regional distribution and density of mGluR1 and the mGluR1 occupancy of drugs in human brains. |
|||||
| 書誌情報 |
European Journal of Nuclear Medicine and Molecular Imaging 巻 39, 号 4, p. 632-641, 発行日 2011-11 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1619-7070 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 22113620 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s00259-011-1995-6 | |||||
