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Central nervous system drug evaluation using positron emission tomography
https://repo.qst.go.jp/records/47214
https://repo.qst.go.jp/records/47214ea13fb83-0fa9-4d73-9b93-39527e8fc0f7
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-08-06 | |||||
| タイトル | ||||||
| タイトル | Central nervous system drug evaluation using positron emission tomography | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Sekine, Mizuho
× Sekine, Mizuho× Maeda, Jun× Shimada, Hitoshi× Nogami, Tsuyoshi× Arakawa, Ryosuke× Takano, Harumasa× Higuchi, Makoto× Ito, Hiroshi× Okubo, Yoshiro× Suhara, Tetsuya× 関根 瑞保× 前田 純× 島田 斉× 野上 毅× 荒川 亮介× 高野 晴成× 樋口 真人× 伊藤 浩× 大久保 善朗× 須原 哲也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In conventional pharmacological research in the field of mental disorders, pharmacological effect and dose have been estimated by ethological approach and in vitro data of affinity to the site of action. In addition, the frequency of administration has been estimated from drug kinetics in blood. However, there is a problem regarding an objective index of drug effects in the living body. Furthermore, the possibility that the concentration of drug in blood does not necessarily reflect the drug kinetics in target organs has been pointed out. Positron emission tomography (PET) techniques have made progress for more than 20 years, and made it possible to measure the distribution and kinetics of small molecule components in living brain. In this article, we focused on rational drug dosing using receptor occupancy and proof-of-concept of drugs in the drug development process using PET. | |||||
| 書誌情報 |
Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology 巻 9, 号 1, p. 9-16, 発行日 2011-04 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1738-1088 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 23431048 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.9758/cpn.2011.9.1.9 | |||||
