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Apathy correlates with prefrontal amyloid β deposition in Alzheimer's disease
https://repo.qst.go.jp/records/47206
https://repo.qst.go.jp/records/47206e8e0585e-8275-402b-b15a-f7e2c51b05ce
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-08-06 | |||||
| タイトル | ||||||
| タイトル | Apathy correlates with prefrontal amyloid β deposition in Alzheimer's disease | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Mori, Takaaki
× Mori, Takaaki× Shimada, Hitoshi× Shinotoh, Hitoshi× Hirano, Sigeki× Eguchi, Yoko× Yamada, Makiko× Fukuhara, Ryuji× Tanimukai, Satoshi× Ming-Rong, Zhang× Kuwabara, Satoshi× Ueno, Shu-ichi× Suhara, Tetsuya× 森 崇明× 島田 斉× 篠遠 仁× 平野 成樹× 江口 洋子× 山田 真希子× 張 明栄× 須原 哲也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objective Neuropsychiatric symptoms affect many patients with Alzheimer's disease (AD). (11C)Pittsburgh Compound-B (PIB) positron emission tomography (PET) has enabled the in vivo visualisation of brain amyloid-β (Aβ) deposition. This study exploratively investigated the correlation between brain Aβ deposition measured by (11C)PIB PET and neuropsychiatric symptoms in AD. \nMethods Participants were 28 patients (15 women, 13 men) with PIB-positive AD. Clinical assessments included Mini-Mental State Examination, Clinical Dementia Rating scale, neuropsychiatry inventory (NPI) and frontal assessment battery. All patients underwent three-dimensional T1-weighted MRI and (11C)PIB PET. The distribution volume ratio (DVR), an index of (11C)PIB retention and, thus, Aβ deposition, was estimated voxel by voxel from (11C)PIB PET data with partial volume correction. Voxel-based correlation analysis was performed to assess the relationships between DVR and each NPI subscale. Additionally, voxel-based analysis of covariance (ANCOVA) of the DVR images was performed between Patients with AD with and without each neuropsychiatric symptom. Voxel-based morphometry analysis of MRI was also performed. \nResults Apathy subscale was correlated with (11C)PIB retention in the bilateral frontal and right anterior cingulate. (11C)PIB retention was greater in the bilateral frontal cortex of patients with AD with apathy than those of without apathy. Overlapping areas between the two analyses were the bilateral orbitofrontal gyrus and left superior frontal gyrus. Other NPI subscales were not correlated with (11C)PIB retention. Voxel-based morphometry analysis of MRI showed no significant cluster of correlation between grey matter volume and NPI subscales. \nConclusions This study revealed that prefrontal Aβ deposition correlates with apathy. |
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| 書誌情報 |
Journal of Neurology, Neurosurgery, and Psychiatry 巻 85, 号 4, p. 449-455, 発行日 2013-10 |
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| 出版者 | ||||||
| 出版者 | the BMJ Publishing Group Ltd. | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0022-3050 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 24133289 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1136/jnnp-2013-306110 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://jnnp.bmj.com/content/early/2013/10/16/jnnp-2013-306110.abstract | |||||
| 関連名称 | http://jnnp.bmj.com/content/early/2013/10/16/jnnp-2013-306110.abstract | |||||
