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Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls.
https://repo.qst.go.jp/records/47205
https://repo.qst.go.jp/records/47205410f2704-7ebc-4e8b-8af0-c523227d2c16
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-08-06 | |||||
| タイトル | ||||||
| タイトル | Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Maruyama, Masahiro
× Maruyama, Masahiro× Shimada, Hitoshi× Suhara, Tetsuya× Shinotoh, Hitoshi× Ji, Bin× Maeda, Jun× Zhang, Ming-Rong× Q, Trojanowski John× M-Y, Lee Virginia× Ono, Maiko× Masamoto, Kazuto× Takano, Harumasa× Sahara, Naruhiko× Iwata, Nobuhisa× Okamura, Nobuyuki× Furumoto, Shozo× Kudo, Yukitsuka× Chang, Qing× C, Saido Takaomi× Takashima, Akihiko× Lewis, Jada× Jang, Ming-Kuei× Aoki, Ichio× Ito, Hiroshi× Higuchi, Makoto× 丸山 将浩× 島田 斉× 須原 哲也× 篠遠 仁× 季 斌× 前田 純× 張 明栄× 小野 麻衣子× 正本 和人× 高野 晴成× 佐原 成彦× 古本 祥三× 青木 伊知男× 伊藤 浩× 樋口 真人 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Accumulation of intracellular tau fibrils has been the focus of research on the mechanisms of neurodegeneration in Alzheimer's disease (AD) and related tauopathies. Here, we have developed a class of tau ligands, phenyl/pyridinyl-butadienyl-benzothiazoles/benzothiazoliums (PBBs), for visualizing diverse tau inclusions in brains of living patients with AD or non-AD tauopathies and animal models of these disorders. In vivo optical and positron emission tomographic (PET) imaging of a transgenic mouse model demonstrated sensitive detection of tau inclusions by PBBs. A pyridinated PBB, [(11)C]PBB3, was next applied in a clinical PET study, and its robust signal in the AD hippocampus wherein tau pathology is enriched contrasted strikingly with that of a senile plaque radioligand, [(11)C]Pittsburgh Compound-B ([(11)C]PIB). [(11)C]PBB3-PET data were also consistent with the spreading of tau pathology with AD progression. Furthermore, increased [(11)C]PBB3 signals were found in a corticobasal syndrome patient negative for [(11)C]PIB-PET. | |||||
| 書誌情報 |
Neuron 巻 79, 号 6, p. 1094-1108, 発行日 2013-09 |
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| 出版者 | ||||||
| 出版者 | Elsevier Inc. | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0896-6273 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 24050400 | |||||
