{"_buckets": {"deposit": "cb691fee-5c35-49da-b1cd-d1f12b2f8a8f"}, "_deposit": {"created_by": 1, "id": "47176", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "47176"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00047176", "sets": ["1"]}, "author_link": ["471444", "471445", "471438", "471437", "471448", "471436", "471439", "471447", "471442", "471441", "471446", "471443", "471449", "471440"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2014-07", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "184", "bibliographicPageStart": "179", "bibliographicVolumeNumber": "3", "bibliographic_titles": [{"bibliographic_title": "Journal of Radiation Oncology"}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Objective\nThis study aims to assess the usefulness of monitoring serum α-fetoprotein (AFP) levels for predicting recurrence patterns in patients with hepatocellular carcinoma (HCC) treated with carbon-ion radiotherapy.\nMethods\nConsecutive 157 HCCs treated with definitive carbon-ion radiotherapy between April 1995 and March 2003 were evaluated. Serum AFP levels were measured before and at 3, 6, 12, and 18 months after treatment. Patterns of recurrence were categorized as local (in field), intrahepatic, or distant. Associations between clinical data and onset of recurrence were analyzed. Patients with AFP level of \u003e20 ng/ml were defined as AFP positive.\nResults\nFollow-up periods were 4.1–66 months (median 35.4 months). Only in the AFP-positive patients, AFP reelevation was associated with the development of recurrence (p = 0.00). Although not statistically significant, patterns of AFP change tended to differ between intrahepatic failure and local failure; AFP levels tended to reelevate earlier in patients developing local failure. Pretreatment AFP of \u003e50 ng/ml (p = 0.00) and total bilirubin of \u003e1.6 mg/dl (p = 0.04) were predictive of development of intrahepatic recurrence within 6 months. AFP of \u003e60 ng/ml (p = 0.00) and platelet of \u003c70,000/mm3 (p = 0.01) were predictive of development of distant metastasis.\nConclusion\nAFP monitoring was useful for patients with HCC treated with carbon-ion radiotherapy. Early AFP reelevation was suggestive of in-field local recurrence.", "subitem_description_type": "Abstract"}]}, "item_8_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Springer "}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1007/s13566-013-0124-5", "subitem_relation_type_select": "DOI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1948-7894", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "柳, 剛"}], "nameIdentifiers": [{"nameIdentifier": "471436", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "安田, 茂雄"}], "nameIdentifiers": [{"nameIdentifier": "471437", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "今田, 浩史"}], "nameIdentifiers": [{"nameIdentifier": "471438", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "山田, 滋"}], "nameIdentifiers": [{"nameIdentifier": "471439", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "加藤, 博敏"}], "nameIdentifiers": [{"nameIdentifier": "471440", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "芝本, 雄太"}], "nameIdentifiers": [{"nameIdentifier": "471441", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "鎌田, 正"}], "nameIdentifiers": [{"nameIdentifier": "471442", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "柳 剛", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "471443", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "安田 茂雄", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "471444", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "今田 浩史", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "471445", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "山田 滋", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "471446", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "加藤 博敏", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "471447", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "芝本 雄太", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "471448", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "鎌田 正", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "471449", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Association between changes in serum α-fetoprotein level and patterns of recurrence in patients undergoing carbon-ion radiotherapy for hepatocellular carcinoma", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Association between changes in serum α-fetoprotein level and patterns of recurrence in patients undergoing carbon-ion radiotherapy for hepatocellular carcinoma"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/47176", "pubdate": {"attribute_name": "公開日", "attribute_value": "2015-07-23"}, "publish_date": "2015-07-23", "publish_status": "0", "recid": "47176", "relation": {}, "relation_version_is_last": true, "title": ["Association between changes in serum α-fetoprotein level and patterns of recurrence in patients undergoing carbon-ion radiotherapy for hepatocellular carcinoma"], "weko_shared_id": -1}