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  1. 原著論文

Association between changes in serum α-fetoprotein level and patterns of recurrence in patients undergoing carbon-ion radiotherapy for hepatocellular carcinoma

https://repo.qst.go.jp/records/47176
https://repo.qst.go.jp/records/47176
1d6ade4e-2bb6-40fe-a279-2f71bf6e463f
Item type 学術雑誌論文 / Journal Article(1)
公開日 2015-07-23
タイトル
タイトル Association between changes in serum α-fetoprotein level and patterns of recurrence in patients undergoing carbon-ion radiotherapy for hepatocellular carcinoma
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 柳, 剛

× 柳, 剛

WEKO 471436

柳, 剛

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安田, 茂雄

× 安田, 茂雄

WEKO 471437

安田, 茂雄

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今田, 浩史

× 今田, 浩史

WEKO 471438

今田, 浩史

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山田, 滋

× 山田, 滋

WEKO 471439

山田, 滋

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加藤, 博敏

× 加藤, 博敏

WEKO 471440

加藤, 博敏

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芝本, 雄太

× 芝本, 雄太

WEKO 471441

芝本, 雄太

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鎌田, 正

× 鎌田, 正

WEKO 471442

鎌田, 正

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柳 剛

× 柳 剛

WEKO 471443

en 柳 剛

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安田 茂雄

× 安田 茂雄

WEKO 471444

en 安田 茂雄

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今田 浩史

× 今田 浩史

WEKO 471445

en 今田 浩史

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山田 滋

× 山田 滋

WEKO 471446

en 山田 滋

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加藤 博敏

× 加藤 博敏

WEKO 471447

en 加藤 博敏

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芝本 雄太

× 芝本 雄太

WEKO 471448

en 芝本 雄太

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鎌田 正

× 鎌田 正

WEKO 471449

en 鎌田 正

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抄録
内容記述タイプ Abstract
内容記述 Objective
This study aims to assess the usefulness of monitoring serum α-fetoprotein (AFP) levels for predicting recurrence patterns in patients with hepatocellular carcinoma (HCC) treated with carbon-ion radiotherapy.
Methods
Consecutive 157 HCCs treated with definitive carbon-ion radiotherapy between April 1995 and March 2003 were evaluated. Serum AFP levels were measured before and at 3, 6, 12, and 18 months after treatment. Patterns of recurrence were categorized as local (in field), intrahepatic, or distant. Associations between clinical data and onset of recurrence were analyzed. Patients with AFP level of >20 ng/ml were defined as AFP positive.
Results
Follow-up periods were 4.1–66 months (median 35.4 months). Only in the AFP-positive patients, AFP reelevation was associated with the development of recurrence (p = 0.00). Although not statistically significant, patterns of AFP change tended to differ between intrahepatic failure and local failure; AFP levels tended to reelevate earlier in patients developing local failure. Pretreatment AFP of >50 ng/ml (p = 0.00) and total bilirubin of >1.6 mg/dl (p = 0.04) were predictive of development of intrahepatic recurrence within 6 months. AFP of >60 ng/ml (p = 0.00) and platelet of <70,000/mm3 (p = 0.01) were predictive of development of distant metastasis.
Conclusion
AFP monitoring was useful for patients with HCC treated with carbon-ion radiotherapy. Early AFP reelevation was suggestive of in-field local recurrence.
書誌情報 Journal of Radiation Oncology

巻 3, 号 2, p. 179-184, 発行日 2014-07
出版者
出版者 Springer
ISSN
収録物識別子タイプ ISSN
収録物識別子 1948-7894
DOI
識別子タイプ DOI
関連識別子 10.1007/s13566-013-0124-5
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