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Association between changes in serum α-fetoprotein level and patterns of recurrence in patients undergoing carbon-ion radiotherapy for hepatocellular carcinoma
https://repo.qst.go.jp/records/47176
https://repo.qst.go.jp/records/471761d6ade4e-2bb6-40fe-a279-2f71bf6e463f
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-07-23 | |||||
| タイトル | ||||||
| タイトル | Association between changes in serum α-fetoprotein level and patterns of recurrence in patients undergoing carbon-ion radiotherapy for hepatocellular carcinoma | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
柳, 剛
× 柳, 剛× 安田, 茂雄× 今田, 浩史× 山田, 滋× 加藤, 博敏× 芝本, 雄太× 鎌田, 正× 柳 剛× 安田 茂雄× 今田 浩史× 山田 滋× 加藤 博敏× 芝本 雄太× 鎌田 正 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objective This study aims to assess the usefulness of monitoring serum α-fetoprotein (AFP) levels for predicting recurrence patterns in patients with hepatocellular carcinoma (HCC) treated with carbon-ion radiotherapy. Methods Consecutive 157 HCCs treated with definitive carbon-ion radiotherapy between April 1995 and March 2003 were evaluated. Serum AFP levels were measured before and at 3, 6, 12, and 18 months after treatment. Patterns of recurrence were categorized as local (in field), intrahepatic, or distant. Associations between clinical data and onset of recurrence were analyzed. Patients with AFP level of >20 ng/ml were defined as AFP positive. Results Follow-up periods were 4.1–66 months (median 35.4 months). Only in the AFP-positive patients, AFP reelevation was associated with the development of recurrence (p = 0.00). Although not statistically significant, patterns of AFP change tended to differ between intrahepatic failure and local failure; AFP levels tended to reelevate earlier in patients developing local failure. Pretreatment AFP of >50 ng/ml (p = 0.00) and total bilirubin of >1.6 mg/dl (p = 0.04) were predictive of development of intrahepatic recurrence within 6 months. AFP of >60 ng/ml (p = 0.00) and platelet of <70,000/mm3 (p = 0.01) were predictive of development of distant metastasis. Conclusion AFP monitoring was useful for patients with HCC treated with carbon-ion radiotherapy. Early AFP reelevation was suggestive of in-field local recurrence. |
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| 書誌情報 |
Journal of Radiation Oncology 巻 3, 号 2, p. 179-184, 発行日 2014-07 |
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| 出版者 | ||||||
| 出版者 | Springer | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1948-7894 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s13566-013-0124-5 | |||||
