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Carbon-ion scanning lung treatment planning with respiratory-gated phase-controlled rescanning: Simulation study using 4-dimensional CT data
https://repo.qst.go.jp/records/47172
https://repo.qst.go.jp/records/47172b3696db4-949f-4f7b-adfe-597448539f21
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-07-22 | |||||
| タイトル | ||||||
| タイトル | Carbon-ion scanning lung treatment planning with respiratory-gated phase-controlled rescanning: Simulation study using 4-dimensional CT data | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Takahashi, Wataru
× Takahashi, Wataru× Mori, Shinichiro× Nakajima, Mio× Yamamoto, Naoyoshi× Inaniwa, Taku× Furukawa, Takuji× Shirai, Toshiyuki× Noda, Koji× Nakagawa, Keiichi× Kamada, Tadashi× 高橋 渉× 森 慎一郎× 中嶋 美緒× 山本 直敬× 稲庭 拓× 古川 卓司× 白井 敏之× 野田 耕司× 中川 恵一× 鎌田 正 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: To moving lung tumors, we applied a respiratory-gated strategy to carbon-ion pencil beam scanning with multiple phase-controlled rescanning (PCR). In this simulation study, we quantitatively evaluated dose distributions based on 4-dimensional CT (4DCT) treatment planning. Methods: Volumetric 4DCTs were acquired for 14 patients with lung tumors. Gross tumor volume, clinical target volume (CTV) and organs at risk (OARs) were delineated. Field-specific target volumes (FTVs) were calculated, and 48Gy(RBE) in a single fraction was prescribed to the FTVs delivered from four beam angles. The dose assessment metrics were quantified by changing the number of PCR and the results for the ungated and gated scenarios were then compared. Results: For the ungated strategy, the mean dose delivered to 95% of the volume of the CTV (CTV-D95) was in average 45.3±0.9 Gy(RBE) even with a single rescanning (1×PCR). Using 4×PCR or more achieved adequate target coverage (CTV-D95 = 46.6±0.3 Gy(RBE) for ungated 4×PCR) and excellent dose homogeneity (homogeneity index = 1.0±0.2% for ungated 4×PCR). Applying respiratory gating, percentage of lung receiving at least 20 Gy(RBE) (lung-V20) and heart maximal dose, averaged over all patients, significantly decreased by 12% (p<0.05) and 13% (p<0.05), respectively. Conclusions: Four or more PCR during PBS-CIRT improved dose conformation to moving lung tumors without gating. The use of a respiratory-gated strategy in combination with PCR reduced excessive doses to OARs. |
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| 書誌情報 |
Radiation Oncology (Online only URL:http://www.ro-journal.com/) 巻 9, p. 238-1-238-9, 発行日 2014-11 |
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| 出版者 | ||||||
| 出版者 | BioMed Central | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1748-717X | |||||
