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Progesterone generates cancer stem cells through membrane progesterone receptor-triggered signaling in basal-like human mammary cells.
https://repo.qst.go.jp/records/47152
https://repo.qst.go.jp/records/47152f1eee0ef-219f-4edb-80d0-20f39639d8e4
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-07-15 | |||||
| タイトル | ||||||
| タイトル | Progesterone generates cancer stem cells through membrane progesterone receptor-triggered signaling in basal-like human mammary cells. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Vares, Guillaume
× Vares, Guillaume× Sai, Sei× Wang, Bing× Fujimori, Akira× Nenoi, Mitsuru× Nakajima, Tetsuo× Ｇｕｉｌｌａｕｍｅ Ｖａｒｅｓ× 崔 星× 王 冰× 藤森 亮× 根井 充× 中島 徹夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Ionizing radiation and cumulative exposure to steroid hormones are known risk factors for breast cancer. There is increasing evidence that breast tumors are driven by a subpopulation of tumor-initiating cancer stem cells (CSCs). In MCF10A non-cancerous basal-like PR(-) cells, progesterone treatment and X-rays generated ALDH(+) and CD44(+)/CD24(-) CSCs. Here, we report that in irradiated MCF10A cells, progesterone activated the PI3k/Akt pathway via membrane progesterone receptor (mPR). Inhibition of the PI3k/Akt pathway counteracted the generation of CSCs by progesterone and irradiation. The stimulation of PI3K/Akt via mPR resulted in the inactivation of FOXO transcriptional activity, the upregulation of snail and slug expression and a downregulation of miR-29 expression, which led to increased levels of KLF4, a transcription factor required for breast CSC maintenance. Stabilization of miR-29 expression impeded the generation of CSCs, while its inhibition alone was sufficient to generate CSCs. This study provides a new mechanistic basis for progesterone and radiation-induced breast cancer risk in basal cells. In addition, the elucidation of new pathways and miRNA regulations involved in CSC generation and maintenance may open the door to potential novel anti-CSC strategies. | |||||
| 書誌情報 |
Cancer letters 巻 362, 号 2, p. 167-173, 発行日 2015-03 |
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| 出版者 | ||||||
| 出版者 | Elsevier Science Ireland | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0304-3835 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 25819032 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.canlet.2015.03.030 | |||||
