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Proliferation following tetraploidization regulates the size and number of erythrocytes in the blood flow during medaka development, as revealed by the abnormal karyotype of erythrocytes in the medaka TFDP1 mutant
https://repo.qst.go.jp/records/47131
https://repo.qst.go.jp/records/471315d9f5644-c424-4c80-94c8-25fcbdadc3c7
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-05-11 | |||||
| タイトル | ||||||
| タイトル | Proliferation following tetraploidization regulates the size and number of erythrocytes in the blood flow during medaka development, as revealed by the abnormal karyotype of erythrocytes in the medaka TFDP1 mutant | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Taimatsu, KIyohito
× Taimatsu, KIyohito× Takubo, Keiyo× Maruyama, Kouichi× Suda, Toshio× Kudo, Akira× 丸山 耕一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | For the delivery of oxygen, the correct size/number of erythrocytes is required for proper blood flow. By combined analyses of wild-type (WT) medaka and the kyoho (kyo) mutant, we found proliferation-mediated adaptation of size/number in erythrocytes for blood flow under active angiogenesis during medaka development. Before the start of heart beating in the WT medaka, the karyotype of erythrocytes was 2N-4N. After the start of blood flow, the karyotype changed to 4N-8N with tetraploidization, and the cell size became larger. After the start of intersegmental and pharyngeal blood flow, the erythrocytes became smaller. The medaka mutant kyo showed erythrocytes of large size, and positional cloning of kyo demonstrated the candidate gene TFDP1, indicating higher polyploidization due to arrest in S phase in flowing erythrocytes of the kyo mutant. From our findings we uncovered a previously unrecognized system for the observed increase in flowing erythrocyte number: proliferation of erythrocytes following tetraploidization is regulated by the tight relationship between erythropoiesis and angiogenesis during embryonic development. | |||||
| 書誌情報 |
Developmental Dynamics 巻 244, 号 5, p. 651-668, 発行日 2015-05 |
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| 出版者 | ||||||
| 出版者 | Wiley | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1058-8388 | |||||
