WEKO3
アイテム
A magnetic anti-cancer compound for magnet-guided delivery and magnetic resonance imaging.
https://repo.qst.go.jp/records/47113
https://repo.qst.go.jp/records/47113464290f0-98e8-49ef-a5ff-fba84e9f3604
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-04-27 | |||||
| タイトル | ||||||
| タイトル | A magnetic anti-cancer compound for magnet-guided delivery and magnetic resonance imaging. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Eguchi, Haruki
× Eguchi, Haruki× Umemura, Masanari× Kurotani, Reiko× Fukumura, Hidenobu× Sato, Itaru× Kim, Jeong-Hwan× Hoshino, Yujiro× Lee, Jin× Amemiya, Naoyuki× Sato, Motohiko× Hirata, Kunio× J, Singh David× Masuda, Takatsugu× Yamamoto, Masahiro× Urano, Tsutomu× Yoshida, Keiichiro× Tanigaki, Katsumi× Yamamoto, Masaki× Sato, Mamoru× Inoue, Seiichi× Aoki, Ichio× Ishikawa, Yoshihiro× 青木 伊知男 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Research on controlled drug delivery for cancer chemotherapy has focused mainly on ways to deliver existing anti-cancer drug compounds to specified targets, e.g., by conjugating them with magnetic particles or encapsulating them in micelles. Here, we show that an iron-salen, i.e., μ-oxo N,N'- bis(salicylidene)ethylenediamine iron (Fe(Salen)), but not other metal salen derivatives, intrinsically exhibits both magnetic character and anti-cancer activity. X-Ray crystallographic analysis and first principles calculations based on the measured structure support this. It promoted apoptosis of various cancer cell lines, likely, via production of reactive oxygen species. In mouse leg tumor and tail melanoma models, Fe(Salen) delivery with magnet caused a robust decrease in tumor size, and the accumulation of Fe(Salen) was visualized by magnetic resonance imaging. Fe(Salen) is an anti-cancer compound with magnetic property, which is suitable for drug delivery and imaging. We believe such magnetic anti-cancer drugs have the potential to greatly advance cancer chemotherapy for new theranostics and drug-delivery strategies. | |||||
| 書誌情報 |
Scientific reports 巻 5, p. 9194, 発行日 2015-03 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2045-2322 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 25779357 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/srep09194 | |||||
