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Evaluation of thermo-triggered drug release in intramuscular-transplanted tumors using thermosensitive polymer-modified liposomes and MRI.
https://repo.qst.go.jp/records/47110
https://repo.qst.go.jp/records/471104b90e90b-d089-41b9-bf77-0bd5cbb337e7
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-04-27 | |||||
| タイトル | ||||||
| タイトル | Evaluation of thermo-triggered drug release in intramuscular-transplanted tumors using thermosensitive polymer-modified liposomes and MRI. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kokuryo, Daisuke
× Kokuryo, Daisuke× Nakashima, Seiji× Ozaki, Fuminori× Yuba, Eiji× Chuang, Kai-Hsiang× Aoshima, Sadahito× Ishizaka, Yukihito× Saga, Tsuneo× Kono, Kenji× Aoki, Ichio× 國領 大介× 石坂 幸人× 佐賀 恒夫× 青木 伊知男 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Multi-modal thermo-sensitive polymer-modified liposomes (MTPLs) containing an anticancer drug, MR contrast agent, and fluorescent dye have been investigated as "theranostic" nanodevices that can be used to monitor drug delivery processes in cancer therapy. Here, we measured the physical characteristics of MTPLs, observed the dynamics of MTPLs in vivo, visualized drug release after heat-triggering using MRI, and evaluated the treatment effects of the MTPLs with and without heating. In vitro experiments demonstrated that the MTPLs released water-soluble drugs at temperatures above 41°C. In vivo MTPLs accumulated in tumor tissue after administration, with a maximum accumulation maintained for 4-12hours. After mild heating for 15minutes, MR signal intensity in the tumor was significantly elevated, indicating release of the contrast agent from the MTPLs was facilitated by heat-triggering. Tumor size after treatment with MTPLs was significantly smaller than those of the control groups. It is concluded that MTPLs with MRI are useful for low-invasive cancer therapy. | |||||
| 書誌情報 |
Nanomedicine : nanotechnology, biology, and medicine 巻 11, 号 1, p. 229-238, 発行日 2014-09 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1549-9634 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 25229542 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.nano.2014.09.001 | |||||
