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  1. 原著論文

TOC1: A valuable tool in assessing disease progression in the rTg4510 mouse model of tauopathy.

https://repo.qst.go.jp/records/47102
https://repo.qst.go.jp/records/47102
e768fd46-c341-44c4-ba6d-8b93b00fc9c7
Item type 学術雑誌論文 / Journal Article(1)
公開日 2015-04-20
タイトル
タイトル TOC1: A valuable tool in assessing disease progression in the rTg4510 mouse model of tauopathy.
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 M, Ward Sarah

× M, Ward Sarah

WEKO 470538

M, Ward Sarah

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S, Himmelstein Diana

× S, Himmelstein Diana

WEKO 470539

S, Himmelstein Diana

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Ren, Yan

× Ren, Yan

WEKO 470540

Ren, Yan

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Fu, Yifan

× Fu, Yifan

WEKO 470541

Fu, Yifan

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Yu, Xiao-Wen

× Yu, Xiao-Wen

WEKO 470542

Yu, Xiao-Wen

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Roberts, Kaleigh

× Roberts, Kaleigh

WEKO 470543

Roberts, Kaleigh

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I, Binder Lester

× I, Binder Lester

WEKO 470544

I, Binder Lester

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Sahara, Naruhiko

× Sahara, Naruhiko

WEKO 470545

Sahara, Naruhiko

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佐原 成彦

× 佐原 成彦

WEKO 470546

en 佐原 成彦

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抄録
内容記述タイプ Abstract
内容記述 All tauopathies result in various forms of cognitive decline and neuronal loss. Although in some diseases, tau mutations appear to cause neurodegeneration, the toxic "form" of tau remains elusive. Tau is the major protein found within neurofibrillary tangles (NFTs) and therefore it seemed rational to assume that aggregation of tau monomers into NFTs was causal to the disease process. However, the appearance of oligomers rather than NFTs coincides much better with the voluminous neuronal loss in many of these diseases. In this study, we utilized the bigenic mouse line (rTg4510) which conditionally expresses P301L human tau. A novel tau antibody, termed Tau Oligomer Complex 1 (TOC1) was employed to probe mouse brains and assess disease progression. TOC1 selectively recognizes dimers/oligomers and appears to constitute an early stage marker of tau pathology. Its peak reactivity is coincident with other well-known early stage pathological markers such as MC1 and the early-stage phospho-marker CP13. TOC1's reactivity depends on the conformation of the tau species since it does not react with monomer under native conditions, although it does react with monomers under SDS-denaturation. This indicates a conformational change must occur within the tau aggregate to expose its epitope. Tau oligomers preferentially form under oxidizing conditions and within this mouse model, we observe tau oligomers forming at an increased rate and persisting much longer, most likely due to the aggressive P301L mutation. With the help of other novel antibodies, the use of this antibody will aid in providing a better understanding of tau toxicity within Alzheimer's disease and other tauopathies.
書誌情報 Neurobiology of disease

巻 67, p. 37-48, 発行日 2014-03
出版者
出版者 Academic Press
ISSN
収録物識別子タイプ ISSN
収録物識別子 0969-9961
PubMed番号
識別子タイプ PMID
関連識別子 24631720
DOI
識別子タイプ DOI
関連識別子 10.1016/j.nbd.2014.03.002
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