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  1. 原著論文

Ionizing radiation, inflammation, and their interactions in colon carcinogenesis in Mlh1-deficient mice.

https://repo.qst.go.jp/records/47081
https://repo.qst.go.jp/records/47081
d4f4f2f1-7cc8-46c2-870c-4b0912ea5a56
Item type 学術雑誌論文 / Journal Article(1)
公開日 2015-04-07
タイトル
タイトル Ionizing radiation, inflammation, and their interactions in colon carcinogenesis in Mlh1-deficient mice.
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Morioka, Takamitsu

× Morioka, Takamitsu

WEKO 470210

Morioka, Takamitsu

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Miyoshi-Imamura, Tomoko

× Miyoshi-Imamura, Tomoko

WEKO 470211

Miyoshi-Imamura, Tomoko

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J, Blyth Benjamin

× J, Blyth Benjamin

WEKO 470212

J, Blyth Benjamin

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Kaminishi, Mutsumi

× Kaminishi, Mutsumi

WEKO 470213

Kaminishi, Mutsumi

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Kokubo, Toshiaki

× Kokubo, Toshiaki

WEKO 470214

Kokubo, Toshiaki

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Nishimura, Mayumi

× Nishimura, Mayumi

WEKO 470215

Nishimura, Mayumi

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Kito, Seiji

× Kito, Seiji

WEKO 470216

Kito, Seiji

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Tokairin, Yutaka

× Tokairin, Yutaka

WEKO 470217

Tokairin, Yutaka

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Tani, Shusuke

× Tani, Shusuke

WEKO 470218

Tani, Shusuke

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Murakami-Murofushi, Kimiko

× Murakami-Murofushi, Kimiko

WEKO 470219

Murakami-Murofushi, Kimiko

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Yoshimi, Naoki

× Yoshimi, Naoki

WEKO 470220

Yoshimi, Naoki

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Shimada, Yoshiya

× Shimada, Yoshiya

WEKO 470221

Shimada, Yoshiya

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Kakinuma, Shizuko

× Kakinuma, Shizuko

WEKO 470222

Kakinuma, Shizuko

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森岡 孝満

× 森岡 孝満

WEKO 470223

en 森岡 孝満

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Blyth Benjamin

× Blyth Benjamin

WEKO 470224

en Blyth Benjamin

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上西 睦美

× 上西 睦美

WEKO 470225

en 上西 睦美

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小久保 年章

× 小久保 年章

WEKO 470226

en 小久保 年章

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西村 まゆみ

× 西村 まゆみ

WEKO 470227

en 西村 まゆみ

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鬼頭 靖司

× 鬼頭 靖司

WEKO 470228

en 鬼頭 靖司

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東海林 裕

× 東海林 裕

WEKO 470229

en 東海林 裕

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谷 修祐

× 谷 修祐

WEKO 470230

en 谷 修祐

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吉見 直己

× 吉見 直己

WEKO 470231

en 吉見 直己

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島田 義也

× 島田 義也

WEKO 470232

en 島田 義也

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柿沼 志津子

× 柿沼 志津子

WEKO 470233

en 柿沼 志津子

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抄録
内容記述タイプ Abstract
内容記述 Genetic, physiological and environmental factors are each implicated in colorectal carcinogenesis. Mutations in the mutL homolog 1 (MLH1) gene, one of the DNA mismatch repair genes, are a main cause of hereditary colon cancer syndromes such as Lynch syndrome. Long-term chronic inflammation is also a key risk factor, responsible for colitis-associated colorectal cancer; and, radiation exposure is also known to increase colorectal cancer risk. Here, we studied the effects of radiation exposure on inflammation-induced colon carcinogenesis in DNA mismatch repair-proficient and -deficient mice. Male and female Mlh1(-/-) and Mlh1(+/+) mice were irradiated with 2 Gy X-rays at 2-weeks-old or 7-weeks-old and/or treated with 1% dextran sodium sulfate (DSS) in drinking water for 7 days at 10-weeks-old to induce mild inflammatory colitis. No colon tumors developed after X-rays and/or DSS treatment in Mlh1(+/+) mice. Colon tumors developed after DSS treatment alone in Mlh1(-/-) mice, and exposure to radiation prior to DSS treatment increased the number of tumors. Histologically, colon tumors in the mice resembled the subtype of well-to-moderately differentiated adenocarcinomas with tumor-infiltrating lymphocytes of human Lynch syndrome. Immunohistochemistry revealed that expression of both p53 and β-catenin and loss of p21 and adenomatosis polyposis coli (Apc) proteins were observed at the later stages of carcinogenesis, suggesting a course of molecular pathogenesis distinct from typical sporadic or colitis-associated colon cancer in humans. In conclusion, radiation exposure could further increase the risk of colorectal carcinogenesis induced by inflammation under the conditions of Mlh1 deficiency. This article is protected by copyright. All rights reserved.
書誌情報 Cancer science

巻 106, 号 3, p. 217-226, 発行日 2015-01
出版者
出版者 Blackwell Publishing
ISSN
収録物識別子タイプ ISSN
収録物識別子 1347-9032
PubMed番号
識別子タイプ PMID
関連識別子 25529563
DOI
識別子タイプ DOI
関連識別子 10.1111/cas.12591
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