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Induced Pluripotent Stem Cell Generation-Associated Point Mutations Arise during the Initial Stages of the Conversion of These Cells.
https://repo.qst.go.jp/records/46973
https://repo.qst.go.jp/records/46973b25683e9-c7e6-4762-90c9-5f3ad2a21a0a
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-11-27 | |||||
| タイトル | ||||||
| タイトル | Induced Pluripotent Stem Cell Generation-Associated Point Mutations Arise during the Initial Stages of the Conversion of These Cells. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Sugiura, Mayumi
× Sugiura, Mayumi× Kasama, Yasuji× Araki, Ryoko× Hoki, Yuko× Sunayama, Misato× Uda, Masahiro× Nakamura, Miki× Ando, Shunsuke× Abe, Masumi× 杉浦 真由美× 笠間 康次× 荒木 良子× 藤森 ゆう子× 砂山 美里× 宇田 昌広× 中村 美樹× 安倍 真澄 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | A large number of point mutations have been identified in induced pluripotent stem cell (iPSC) genomes to date. Whether these mutations are associated with iPSC generation is an important and controversial issue. In this study, we approached this critical issue in different ways, including an assessment of iPSCs versus embryonic stem cells (ESCs), and an investigation of variant allele frequencies and the heterogeneity of point mutations within a single iPSC clone. Through these analyses, we obtained strong evidence that iPSC-generation-associated point mutations occur frequently in a transversion-predominant manner just after the onset of cell lineage conversion. The heterogeneity of the point mutation profiles within an iPSC clone was also revealed and reflects the history of the emergence of each mutation. Further, our results suggest a possible approach for establishing iPSCs with fewer point mutations. | |||||
| 書誌情報 |
Stem cell reports 巻 2, 号 1, p. 52-63, 発行日 2014-01 |
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| 出版者 | ||||||
| 出版者 | Cell Press | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 24511470 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.cell.com/stem-cell-reports/fulltext/S2213-6711%2813%2900131-8 | |||||
| 関連名称 | http://www.cell.com/stem-cell-reports/fulltext/S2213-6711%2813%2900131-8 | |||||
