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Clinical Impact of Radiation-Resistant Mesenchymal Stem Cells in Bone Marrow Deduced from Preclinical Studies
https://repo.qst.go.jp/records/46951
https://repo.qst.go.jp/records/4695159ee2a93-e8fa-4d48-8511-d142f413e80c
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-11-18 | |||||
| タイトル | ||||||
| タイトル | Clinical Impact of Radiation-Resistant Mesenchymal Stem Cells in Bone Marrow Deduced from Preclinical Studies | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Michikawa, Yuichi
× Michikawa, Yuichi× Hazawa, Masaharu× Saotome, Ai× Yasuda, Takeshi× Gotoh, Takaya× Tajima, Katsushi× 道川 祐市× 羽澤 勝治× 早乙女 愛× 安田 武嗣× 後藤 孝也× 田嶋 克史 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Mesenchymal stem cells in the bone marrow have attracted great interest over the past decades, not only as a basic scientific subject but also as a novel and advanced clinical tool. More than 300 mesenchymal stem cell-related clinical trials are currently registered in the world. Hematopoietic stem cells in bone marrow are extremely radiation-sensitive, whereas mesenchymal stem cells show considerable radiation-resistance. Intrinsic cellular mechanisms, including highly efficient reactive oxygen species-scavenging ability and active DNA damage response pathways, have been reported to explain the radiation-resistance of mesenchymal stem cells in the bone marrow. The precise interactions between residual host mesenchymal stem cells and donor mesenchymal stem cells at the time of bone marrow transplantation following whole-body irradiation, however, remain unknown. This short review summarizes our current understanding of the clinical impact of the radiation-resistance of endogenous mesenchymal stem cells in the bone marrow. | |||||
| 書誌情報 |
Journal of Bone Marrow Research (Online Only URL:http://www.esciencecentral.org/journals/bone-marrow-research.php) 巻 1, 号 1, p. 101, 発行日 2013-02 |
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| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.4172/jbmr.1000101 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.esciencecentral.org/journals/JBMR/JBMR-1-101.php??aid=11737 | |||||
| 関連名称 | http://www.esciencecentral.org/journals/JBMR/JBMR-1-101.php??aid=11737 | |||||
