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  1. 原著論文

Extension of lifespan and protection against oxidative stress by an antioxidant herb mixture complex (KPG-7) in Caenorhabditis elegans.

https://repo.qst.go.jp/records/46947
https://repo.qst.go.jp/records/46947
a7acc12d-599c-4f41-bfb9-3429b56130bd
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-11-17
タイトル
タイトル Extension of lifespan and protection against oxidative stress by an antioxidant herb mixture complex (KPG-7) in Caenorhabditis elegans.
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Moriwaki, Takahito

× Moriwaki, Takahito

WEKO 468500

Moriwaki, Takahito

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Kato, Seiji

× Kato, Seiji

WEKO 468501

Kato, Seiji

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Kato, Yuichi

× Kato, Yuichi

WEKO 468502

Kato, Yuichi

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Hosoki, Ayaka

× Hosoki, Ayaka

WEKO 468503

Hosoki, Ayaka

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Zhang-Akiyama, Qiu-Mei

× Zhang-Akiyama, Qiu-Mei

WEKO 468504

Zhang-Akiyama, Qiu-Mei

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細木 彩夏

× 細木 彩夏

WEKO 468505

en 細木 彩夏

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抄録
内容記述タイプ Abstract
内容記述 Excessive generation of reactive oxygen species within cells results in oxidative stress. Furthermore, accumulation of reactive oxygen species has been shown to reduce cell longevity. Many dietary supplements are believed to have anti-aging effects. The herb mixture KPG-7 contains several components with antioxidant activity. We aim to clarify the mechanisms responsible for the antioxidant activity of KPG-7 and to establish whether KPG-7 has an anti-aging effect. We examined whether dietary supplementation with KPG-7 could provide protection against oxidative stress, extend lifespan, and delay aging in Caenorhabditis elegans (C. elegans). We found that KPG-7 extended lifespan and delayed aging in adult C. elegans. The expression of oxidation resistance 1 protein was induced by juglone and this effect was significantly suppressed in KPG-7-treated. In addition, the amount of oxidized protein was significantly lower in KPG-7-treated worms than untreated worms. Furthermore, locomotive activity was increased in C. elegans at 3 days of age following the treatment with KPG-7. On the other hand, the level of cellular ATP was lower at 3 days of age in worms treated with KPG-7 than in untreated worms. KPG-7 increases lifespan and delays aging in C. elegans, well corresponding to its activity to protect against oxidative stress.
書誌情報 Journal of clinical biochemistry and nutrition

巻 53, 号 2, p. 81-88, 発行日 2013-09
出版者
出版者 Institute Of Applied Biochemistry
ISSN
収録物識別子タイプ ISSN
収録物識別子 0912-0009
PubMed番号
識別子タイプ PMID
関連識別子 24062604
DOI
識別子タイプ DOI
関連識別子 10.3164/jcbn.13-11
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