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Compartmental analysis of washout effect in rat brain: in-beam OpenPET measurement using a (11)C beam.
https://repo.qst.go.jp/records/46924
https://repo.qst.go.jp/records/4692429eb8734-50cf-42e6-9302-da251bee546d
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-11-10 | |||||
| タイトル | ||||||
| タイトル | Compartmental analysis of washout effect in rat brain: in-beam OpenPET measurement using a (11)C beam. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hirano, Yoshiyuki
× Hirano, Yoshiyuki× Kinouchi, Shoko× Ikoma, Yoko× Yoshida, Eiji× Wakizaka, Hidekazu× Ito, Hiroshi× Yamaya, Taiga× 平野 祥之× 生駒 洋子× 吉田 英治× 脇坂 秀克× 伊藤 浩× 山谷 泰賀 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In-beam positron emission tomography (PET) is expected to enable visualization of a dose verification using positron emitters (β+ decay). For accurate dose verification, correction of the washout of the positron emitters should be made. In addition, the quantitative washout rate has a potential usefulness as a diagnostic index, but modeling for this has not been studied yet. In this paper, therefore, we applied compartment analyses to in-beam PET data acquired by our small OpenPET prototype, which has a physically opened field-of-view (FOV) between two detector rings. A rat brain was located at the FOV and was irradiated by a (11)C beam. Time activity curves of the irradiated field were measured immediately after the irradiations, and the washout rate was obtained based on two models: the two-washout model (medium decay, k2m; slow decay, k2s) developed in a study of rabbit irradiation; and the two-compartment model used in nuclear medicine, where efflux from tissue to blood (k2), influx (k3) and efflux (k4) from the first to second compartments in tissue were evaluated. The observed k2m and k2s were 0.34 and 0.005 min(-1), respectively, which was consistent with the rabbit study. Also k2m was close to the washout rate in cerebral blood flow (CBF) measurements by dynamic PET with (15)O-water, while, k2, k3, and k4 were 0.16, 0.15 and 0.007 min(-1). Our present work suggested the dynamics of (11)C might be relevant to CBF or permeability of a molecule containing (11)C atoms might be regulated by a transporter because the k2 was relatively low compared with a simple diffusion tracer. | |||||
| 書誌情報 |
Physics in medicine and biology 巻 58, 号 23, p. 8281-8294, 発行日 2013-11 |
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| 出版者 | ||||||
| 出版者 | IOP PUBLISHING | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0031-9155 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 24216504 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1088/0031-9155/58/23/8281 | |||||
