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  1. 原著論文

Microvascular sprouting, extension, and creation of new capillary connections with adaptation of the neighboring astrocytes in adult muose cortex under chronic hypoxia

https://repo.qst.go.jp/records/46907
https://repo.qst.go.jp/records/46907
ce2fc0be-40f8-4b15-ba20-1007c380eb47
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-11-07
タイトル
タイトル Microvascular sprouting, extension, and creation of new capillary connections with adaptation of the neighboring astrocytes in adult muose cortex under chronic hypoxia
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Masamoto, Kazuto

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Masamoto, Kazuto

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Takuwa, Hiroyuki

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Takuwa, Hiroyuki

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Seki, Chie

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Seki, Chie

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Taniguchi, Junko

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Itoh, Yoshiaki

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Itoh, Yoshiaki

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Tomita, Yutaka

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Toriumi, Haruki

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Toriumi, Haruki

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Unekawa, Miyuki

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Kawaguchi, Hiroshi

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Ito, Hiroshi

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Suzuki, Norihiro

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Suzuki, Norihiro

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Kanno, Iwao

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Kanno, Iwao

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正本 和人

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田桑 弘之

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関 千江

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谷口 順子

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川口 拓之

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伊藤 浩

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菅野 巖

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抄録
内容記述タイプ Abstract
内容記述 The present study aimed to determine the spatiotemporal dynamics of microvascular and astrocytic adaptation during hypoxia-induced cerebral angiogenesis. Adult C57BL/6J and Tie2-green fluorescent protein (GFP) mice with vascular endothelial cells expressing GFP were exposed to normobaric hypoxia for 3 weeks, whereas the three-dimensional microvessels and astrocytes were imaged repeatedly using two-photon microscopy. After 7 to14 days of hypoxia, a vessel sprout appeared from the capillaries with a bump-like head shape (mean diameter 14 μm), and stagnant blood cells were seen inside the sprout. However, no detectable changes in the astrocyte morphology were observed for this early phase of the hypoxia adaptation. More than 50% of the sprouts emerged from capillaries 60 μm away from the center penetrating arteries, which indicates that the capillary distant from the penetrating arteries is a favored site for sprouting. After 14 to 21 days of hypoxia, the sprouting vessels created a new connection with an existing capillary. In this phase, the shape of the new vessel and its blood flow were normalized, and the outside of the vessels were wrapped with numerous processes from the neighboring astrocytes. The findings indicate that hypoxia-induced cerebral angiogenesis provokes the adaptation of neighboring astrocytes, which may stabilize the blood–brain barrier in immature vessels.
書誌情報 Journal of Cerebral Blood Flow & Metabolism

巻 34, 号 2, p. 325-331, 発行日 2013-11
出版者
出版者 Nature Publishing Group
ISSN
収録物識別子タイプ ISSN
収録物識別子 0271-678X
PubMed番号
識別子タイプ PMID
関連識別子 24252848
DOI
識別子タイプ DOI
関連識別子 10.1038/jcbfm.2013.201
関連サイト
識別子タイプ URI
関連識別子 http://www.nature.com/jcbfm/journal/vaop/ncurrent/full/jcbfm2013201a.html
関連名称 http://www.nature.com/jcbfm/journal/vaop/ncurrent/full/jcbfm2013201a.html
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