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A serial 4DCT study to quantify range variations in charged particle radiotherapy of thoracic cancers
https://repo.qst.go.jp/records/46897
https://repo.qst.go.jp/records/46897b48639fa-d878-42e3-8a06-12c7e74f9444
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-11-06 | |||||
| タイトル | ||||||
| タイトル | A serial 4DCT study to quantify range variations in charged particle radiotherapy of thoracic cancers | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Mori, Shinichiro
× Mori, Shinichiro× Lei, DONG× STARKSCHALL, George× MOHAN, Radhe× T.Y., CHEN George× 森 慎一郎 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Weekly serial 4DCT scans were acquired under free breathing conditions to assess water equivalent pathlength (WEL) variations due to both intrafractional and interfractional changes in tissue thickness and density and to calculate proton dose distributions resulting from anatomical variations observed in serial 4DCT. A template of ROIs was defined on the anterior-posterior (AP) beam’s eye view and WEL measurements were made over these ROIs to quantify chest wall thickness variations. Interfractional proton dose distributions were calculated to assess changes in the expected dose distributions caused by range variations. Mean intrafractional chest wall WEL changes during respiration varied by: -4.1mm(<-10.2mm), -3.6 mm(<-7.1mm), -3.2mm(<-5.6mm), -2.5mm(<-5.1mm) during respiration in the ITV, upper, middle and lower lung regions respectively. The mean interfractional chest wall WEL variation at week6 decreased by -4.0mm(<-8.6mm), -9.1mm(<-17.9mm), -9.4mm(<-25.3mm), -4.5mm(<-15.6mm) in the ITV, upper, middle and lower lung regions respectively. The variations were decomposed into anterior and posterior chest wall thickness changes. Dose overshoot beyond the target was observed when the initial boli was applied throughout the treatment course. This overshoot is due to chest wall thickness variations and target positional variations. The radiological pathlength can vary significantly during respiration as well as over the course of several weeks of charged particle therapy. Intrafractional/interfractional chest wall thickness changes can be a significant source of range variation in treatment of lung tumors with charged particle beams, resulting in dose distribution perturbations from the initial plan. Consideration of these range variations should be considered in choosing the therapeutic charged particle beam range. |
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| 書誌情報 |
Journal of radiation research 巻 55, 号 2, p. 309-319, 発行日 2013-10 |
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| 出版者 | ||||||
| 出版者 | Oxford University Press | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1093/jrr/rrt114 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://jrr.oxfordjournals.org/content/early/2013/10/18/jrr.rrt114.full?sid=9e76b66a-a0b3-4860-bf1a-e4e2232724ba | |||||
| 関連名称 | http://jrr.oxfordjournals.org/content/early/2013/10/18/jrr.rrt114.full?sid=9e76b66a-a0b3-4860-bf1a-e4e2232724ba | |||||
