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Modeling the biological response of normal human cells, including repair processes, to fractionated carbon beam irradiation.
https://repo.qst.go.jp/records/46895
https://repo.qst.go.jp/records/46895aa47089d-c441-45ff-8d85-c7c19f0ca0c1
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-11-06 | |||||
| タイトル | ||||||
| タイトル | Modeling the biological response of normal human cells, including repair processes, to fractionated carbon beam irradiation. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Wada, Mami
× Wada, Mami× Suzuki, Masao× Hua, Liu Cui× Kaneko, Yumiko× Fukuda, Shigekazu× Ando, Koichi× Matsufuji, Naruhiro× 和田 麻美× 鈴木 雅雄× 劉 翠華× 金子 由美子× 福田 茂一× 松藤 成弘 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To understand the biological response of normal cells to fractionated carbon beam irradiation, the effects of potentially lethal damage repair (PLDR) and sublethal damage repair (SLDR) were both taken into account in a linear-quadratic (LQ) model. The model was verified by the results of a fractionated cell survival experiment with normal human fibroblast cells. Cells were irradiated with 200-kV X-rays and monoenergetic carbon ion beams (290 MeV/u) at two irradiation depths, corresponding to linear energy transfers (LETs) of approximately 13 keV/um and 75 keV/um, respectively, at the Heavy Ion Medical Accelerator in Chiba of the National Institute of Radiological Sciences. When we only took into account the repair factor of PLDR, gamma, which was derived from the delayed assay, the cell survival response to fractionated carbon ion irradiation was not fully explained in some cases. When both the effects of SLDR and PLDR were taken into account in the LQ model, the cell survival response was well reproduced. The model analysis suggested that PLDR occurs in any type of radiation. The gamma factors ranged from 0.36-0.93. In addition, SLD was perfectly repaired during the fraction interval for the lower LET irradiations but remained at about 30% for the high-LET irradiation. | |||||
| 書誌情報 |
Journal of Radiation Research 巻 54, 号 5, p. 798-807, 発行日 2013-09 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0449-3060 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1093/jrr/rrt012 | |||||
