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Effects of menopause on brain structural changes in schizophrenia.
https://repo.qst.go.jp/records/46879
https://repo.qst.go.jp/records/46879ecd87f09-7787-4822-b128-328c72b01486
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-11-20 | |||||
| タイトル | ||||||
| タイトル | Effects of menopause on brain structural changes in schizophrenia. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Fukuta, Hajime
× Fukuta, Hajime× Ito, Itsuo× Tateno, Amane× Nogami, Tsuyoshi× Taiji, Yasutomo× Arakawa, Ryosuke× Suhara, Tetsuya× Asai, Kunihiko× Okubo, Yoshiro× Arakawa, Ryosuke× Suhara, Tetsuya |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | AIM:The aim of this study was to investigate the influences of menopause on brain morphological changes in schizophrenia using magnetic resonance imaging (MRI). METHODS:Forty female schizophrenia patients, 20 premenopausal and 20 postmenopausal, and 50 female controls underwent cerebral MRI. Optimized voxel-based morphometry was performed with Statistical Parametric Mapping version 5. RESULTS:Compared with controls, regional gray matter reductions in schizophrenia patients were observed in the insula, superior temporal gyrus, anterior cingulate, parahippocampal gyrus, and thalamus. Direct comparison between the patient groups showed that the gray matter of postmenopausal patients was significantly smaller when compared with premenopausal patients in the left middle frontal gyrus, and no region had significantly lower gray matter volume in premenopausal patients relative to postmenopausal patients. Significant negative correlation between gray matter volume and the interval after menopause was found in the right superior frontal gyrus in the postmenopause patient group. CONCLUSION:Differential morphological alterations between postmenopausal and premenopausal schizophrenia patients were observed, suggesting that the female hormone plays a protective role against schizophrenia. |
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| 書誌情報 |
Psychiatry and clinical neurosciences 巻 67, 号 1, p. 3-11, 発行日 2013-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1323-1316 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 23331283 | |||||
