WEKO3
アイテム
Tau Oligomers as Potential Targets for Early Diagnosis of Tauopathy.
https://repo.qst.go.jp/records/46859
https://repo.qst.go.jp/records/468596d954f20-a04a-4edd-9148-67125840d3a4
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-10-20 | |||||
| タイトル | ||||||
| タイトル | Tau Oligomers as Potential Targets for Early Diagnosis of Tauopathy. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Sahara, Naruhiko
× Sahara, Naruhiko× Ren, Yan× Ward, Sarah× I, Binder Lester× Suhara, Tetsuya× Higuchi, Makoto× 佐原 成彦× 須原 哲也× 樋口 真人 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The discovery of tau mutations in frontotemporal dementia has been a key event in neurodegenerative disease research. The rTg4510 mouse line expressing human tau with P301L FTDP-17-tau mutation has been established to understand the role of tau in neurodegeneration. Our histological analyses with tau antibodies and fluorescent tau ligands on rTg4510 mice revealed that tau oligomer formation was distinct from tangle formation. While in vivo imaging of mature tangles is now available, imaging biomarkers for tau oligomers would be useful for clarifying their roles in neurotoxicity and for diagnosing early-stage tau pathology. | |||||
| 書誌情報 |
Journal of Alzheimer's disease : JAD 巻 40, 号 S1, p. S91-S96, 発行日 2014-03 |
|||||
| 出版者 | ||||||
| 出版者 | IOS press | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1387-2877 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 24595194 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3233/JAD-132429 | |||||
