WEKO3
アイテム
Simulated studies on the biological effects of space radiation on quiescent human fibroblasts
https://repo.qst.go.jp/records/46855
https://repo.qst.go.jp/records/468550a1dbf9f-2561-4e22-a8ce-99aa8126cb28
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-10-20 | |||||
| タイトル | ||||||
| タイトル | Simulated studies on the biological effects of space radiation on quiescent human fibroblasts | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ding, Nan
× Ding, Nan× Pei, Hailong× He, Jinpeng× Furusawa, Yoshiya× Hirayama, Ryoichi× Liu, Cuihua× Matsumoto, Yoshitaka× Li, He× Hu, Wentao× Li, Yinghui× Wang, Jufang× Wang, Tieshan× Zhou, Guangming× 古澤 佳也× 平山 亮一× 劉 翠華× 松本 孔貴× 周 光明 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | High charge and energy (HZE) particles are severe risk to manned long-term outer space exploration. Studies on the biological effects of space HZE particles and the underlying mechanisms are essential to the accurate risk assessment and the development of efficient countermeasure. Since majority of the cells in human body stay quiescent (G0 phase), in this study, we established G0 cell and G1 cell models by releasing human normal embryonic lung fibroblast cells from contact inhibition and studied the radiation toxicity of various kinds of HZE particles. Results showed that all of the particles were dose-dependently lethal and G0 cells were more radio resistant than G1 cells. We also found that 53BP1 foci were induced in a LET- and fluence-dependent manner and fewer foci were induced in G0 cells than G1 cells, however, the decrease of foci in 24 h after irradiation was highly relevant to the type of particles. These results imply that even though health risk of space radiation is probably overestimated by the data obtained with exponentially growing cells, whose radio sensitivity is similar to G1 cells, the risk of space HZE particles is un-ignorable and accurate assessment and mechanistic studies should be deepened. The diverse abilities of G0 cells and G1 cells in repairing DNA damages induced by HZE particles emphasize the importance in studying the impact of HZE particles on DNA damage repair pathways. |
|||||
| 書誌情報 |
Advances in Space Research 巻 52, 号 7, p. 1314-1319, 発行日 2013-11 |
|||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0273-1177 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.asr.2013.06.030 | |||||
