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Molecular characterization of cancer reveals interactions between ionizing radiation and chemicals on rat mammary carcinogenesis
https://repo.qst.go.jp/records/46853
https://repo.qst.go.jp/records/46853a67cbe32-7907-4bbe-8436-7d92c823f899
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-10-20 | |||||
| タイトル | ||||||
| タイトル | Molecular characterization of cancer reveals interactions between ionizing radiation and chemicals on rat mammary carcinogenesis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Imaoka, Tatsuhiko
× Imaoka, Tatsuhiko× Nishimura, Mayumi× Doi, Kazutaka× Tani, Shusuke× Ishikawa, Ken-ichi× Yamashita, Satoshi× Ushijima, Toshikazu× Imai, Takashi× Shimada, Yoshiya× 今岡 達彦× 西村 まゆみ× 土居 主尚× 谷 修祐× 石川 顕一× 今井 高志× 島田 義也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Although various mechanisms have been inferred for combinatorial actions of multiple carcinogens, these mechanisms have not been well demonstrated in experimental carcinogenesis models. We evaluated mammary carcinogenesis initiated by combined exposure to various doses of radiation and chemical carcinogens. Female rats at 7 weeks of age were gamma-irradiated (0.2–2 Gy) and/or exposed to 1-methyl-1-nitrosourea (20 or 40 mg/kg, single intraperitoneal injection) or 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (40 mg/kg/day by gavage for 10 days) and were observed until 50 weeks of age. The incidence of mammary carcinoma increased steadily as a function of radiation dose in the absence of chemicals; mathematical analysis supported an additive increase when radiation was combined with a chemical carcinogen, irrespective of the chemical species and its dose. Hras mutations were characteristic of carcinomas that developed after chemical carcinogen treatments and were overrepresented in carcinomas induced by the combination of radiation and MNU (but not PhIP), indicating an interaction of radiation and MNU at the level of initiation. The expression profiles of seven classifier genes, previously shown to distinguish two classes of rat mammary carcinomas, categorized almost all examined carcinomas that developed after individual or combined treatments with radiation (1 Gy) and chemicals as belonging to a single class; more comprehensive screening using microarrays and a separate test sample set failed to identify differences in gene expression profiles among these carcinomas. These results suggest that a complex, multilevel interaction underlies the combinatorial action of radiation and chemical carcinogens in the experimental model. | |||||
| 書誌情報 |
International Journal of Cancer 巻 134, 号 7, p. 1529-1538, 発行日 2014-01 |
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| 出版者 | ||||||
| 出版者 | Wiley | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0020-7136 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1002/ijc.28480 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://onlinelibrary.wiley.com/doi/10.1002/ijc.v134.7/issuetoc | |||||
| 関連名称 | http://onlinelibrary.wiley.com/doi/10.1002/ijc.v134.7/issuetoc | |||||
