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  1. 原著論文

Molecular characterization of cancer reveals interactions between ionizing radiation and chemicals on rat mammary carcinogenesis

https://repo.qst.go.jp/records/46853
https://repo.qst.go.jp/records/46853
a67cbe32-7907-4bbe-8436-7d92c823f899
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-10-20
タイトル
タイトル Molecular characterization of cancer reveals interactions between ionizing radiation and chemicals on rat mammary carcinogenesis
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Imaoka, Tatsuhiko

× Imaoka, Tatsuhiko

WEKO 467425

Imaoka, Tatsuhiko

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Nishimura, Mayumi

× Nishimura, Mayumi

WEKO 467426

Nishimura, Mayumi

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Doi, Kazutaka

× Doi, Kazutaka

WEKO 467427

Doi, Kazutaka

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Tani, Shusuke

× Tani, Shusuke

WEKO 467428

Tani, Shusuke

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Ishikawa, Ken-ichi

× Ishikawa, Ken-ichi

WEKO 467429

Ishikawa, Ken-ichi

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Yamashita, Satoshi

× Yamashita, Satoshi

WEKO 467430

Yamashita, Satoshi

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Ushijima, Toshikazu

× Ushijima, Toshikazu

WEKO 467431

Ushijima, Toshikazu

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Imai, Takashi

× Imai, Takashi

WEKO 467432

Imai, Takashi

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Shimada, Yoshiya

× Shimada, Yoshiya

WEKO 467433

Shimada, Yoshiya

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今岡 達彦

× 今岡 達彦

WEKO 467434

en 今岡 達彦

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西村 まゆみ

× 西村 まゆみ

WEKO 467435

en 西村 まゆみ

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土居 主尚

× 土居 主尚

WEKO 467436

en 土居 主尚

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谷 修祐

× 谷 修祐

WEKO 467437

en 谷 修祐

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石川 顕一

× 石川 顕一

WEKO 467438

en 石川 顕一

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今井 高志

× 今井 高志

WEKO 467439

en 今井 高志

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島田 義也

× 島田 義也

WEKO 467440

en 島田 義也

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抄録
内容記述タイプ Abstract
内容記述 Although various mechanisms have been inferred for combinatorial actions of multiple carcinogens, these mechanisms have not been well demonstrated in experimental carcinogenesis models. We evaluated mammary carcinogenesis initiated by combined exposure to various doses of radiation and chemical carcinogens. Female rats at 7 weeks of age were gamma-irradiated (0.2–2 Gy) and/or exposed to 1-methyl-1-nitrosourea (20 or 40 mg/kg, single intraperitoneal injection) or 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (40 mg/kg/day by gavage for 10 days) and were observed until 50 weeks of age. The incidence of mammary carcinoma increased steadily as a function of radiation dose in the absence of chemicals; mathematical analysis supported an additive increase when radiation was combined with a chemical carcinogen, irrespective of the chemical species and its dose. Hras mutations were characteristic of carcinomas that developed after chemical carcinogen treatments and were overrepresented in carcinomas induced by the combination of radiation and MNU (but not PhIP), indicating an interaction of radiation and MNU at the level of initiation. The expression profiles of seven classifier genes, previously shown to distinguish two classes of rat mammary carcinomas, categorized almost all examined carcinomas that developed after individual or combined treatments with radiation (1 Gy) and chemicals as belonging to a single class; more comprehensive screening using microarrays and a separate test sample set failed to identify differences in gene expression profiles among these carcinomas. These results suggest that a complex, multilevel interaction underlies the combinatorial action of radiation and chemical carcinogens in the experimental model.
書誌情報 International Journal of Cancer

巻 134, 号 7, p. 1529-1538, 発行日 2014-01
出版者
出版者 Wiley
ISSN
収録物識別子タイプ ISSN
収録物識別子 0020-7136
DOI
識別子タイプ DOI
関連識別子 10.1002/ijc.28480
関連サイト
識別子タイプ URI
関連識別子 http://onlinelibrary.wiley.com/doi/10.1002/ijc.v134.7/issuetoc
関連名称 http://onlinelibrary.wiley.com/doi/10.1002/ijc.v134.7/issuetoc
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