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Reduction method for intrinsic random coincidence events from (176)Lu in low activity PET imaging.
https://repo.qst.go.jp/records/46815
https://repo.qst.go.jp/records/46815daaf5fee-5737-4073-8048-4723cd97763a
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-09-01 | |||||
| タイトル | ||||||
| タイトル | Reduction method for intrinsic random coincidence events from (176)Lu in low activity PET imaging. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yoshida, Eiji
× Yoshida, Eiji× Tashima, Hideaki× Nishikido, Fumihiko× Murayama, Hideo× Yamaya, Taiga× 吉田 英治× 田島 英朗× 錦戸 文彦× 村山 秀雄× 山谷 泰賀 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | For clinical studies, the effects of the intrinsic radioactivity of lutetium-based scintillators such as LSO used in PET imaging can be ignored within a narrow energy window. However, the intrinsic radioactivity becomes problematic when used in low-count-rate situations such as gene expression imaging or in-beam PET imaging. Time-of-flight (TOF) measurement capability promises not only to improve PET image quality, but also to reduce intrinsic random coincidences. On the other hand, we have developed a new reduction method for intrinsic random coincidence events based on multiple-coincidence information. Without the energy window, an intrinsic random coincidence is detected simultaneously with an intrinsic true coincidence as a multiple coincidence. The multiple-coincidence events can serve as a guide to identification of the intrinsic coincidences. After rejection of multiple-coincidence events detected with a wide energy window, data obtained included a few intrinsic random and many intrinsic true coincidence events. We analyzed the effect of intrinsic radioactivity and used Monte Carlo simulation to test both the TOF-based method and the developed multiple-coincidence-based (MC-based) method for a whole-body LSO-PET scanner. Using the TOF- and MC-based reduction methods separately, we could reduce the intrinsic random coincidence rates by 77 and 30 %, respectively. Also, the intrinsic random coincidence rate could be reduced by 84 % when the TOF+MC reduction methods were applied. The developed MC-based method showed reduced number of the intrinsic random coincidence events, but the reduction performance was limited compared to that of the TOF-based reduction method. | |||||
| 書誌情報 |
Radiological physics and technology 巻 7, 号 2, p. 235-245, 発行日 2014-07 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1865-0333 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 24496884 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s12194-014-0258-1 | |||||
