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Enhanced radiobiological effects at the distal end of a clinical proton beam: in vitro study
https://repo.qst.go.jp/records/46807
https://repo.qst.go.jp/records/46807dfa71922-99ef-4080-81db-f8ccfbbb86e3
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-08-20 | |||||
| タイトル | ||||||
| タイトル | Enhanced radiobiological effects at the distal end of a clinical proton beam: in vitro study | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Matsumoto, Yoshitaka
× Matsumoto, Yoshitaka× Taeko, Matsuura× Wada, Mami× Yusuke, Egashira× Nishio, Teiji× Furusawa, Yoshiya× 松本 孔貴× 和田 麻美× 古澤 佳也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In the clinic, the relative biological effectiveness (RBE) value of 1.1 has usually been used in relation to the whole depth of the spread-out Bragg-peak (SOBP) of proton beams. The aim of this study was to confirm the actual biological effect in the SOBP at the very distal end of clinical proton beams using an in vitro cell system. A human salivary gland tumor cell line, HSG, was irradiated with clinical proton beams (accelerated by 190 MeV/u) and examined at different depths in the distal part and the center of the SOBP. Surviving fractions were analyzed with the colony formation assay. Cell survival curves and the survival parameters were obtained by fitting with the linear–quadratic (LQ) model. The RBE at each depth of the proton SOBP compared with that for X-rays was calculated by the biological equivalent dose, and the biological dose distribution was calculated from the RBE and the absorbed dose at each position. Although the physical dose distribution was flat in the SOBP, the RBE values calculated by the equivalent dose were significantly higher (up to 1.56 times) at the distal end than at the center of the SOBP. Additionally, the range of the isoeffective dose was extended beyond the range of the SOBP (up to 4.1 mm). From a clinical point of view, this may cause unexpected side effects to normal tissues at the distal position of the beam. It is important that the beam design and treatment planning take into consideration the biological dose distribution. | |||||
| 書誌情報 |
Journal of Radiation Research 巻 55, 号 4, p. 816-822, 発行日 2014-05 |
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| 出版者 | ||||||
| 出版者 | Oxford University Press | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0449-3060 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 24824674 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1093/jrr/rrt230 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://jrr.oxfordjournals.org/content/early/2014/05/13/jrr.rrt230.abstract?sid=3afc5480-20a9-45ef-9ec6-3ba2c64c1da5 | |||||
| 関連名称 | http://jrr.oxfordjournals.org/content/early/2014/05/13/jrr.rrt230.abstract?sid=3afc5480-20a9-45ef-9ec6-3ba2c64c1da5 | |||||
