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Cerebral hemodynamic response to acute hyperoxia in awake mice.
https://repo.qst.go.jp/records/46795
https://repo.qst.go.jp/records/46795604990fc-40c4-4e9a-a7ab-4b4704ba8041
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-07-29 | |||||
| タイトル | ||||||
| タイトル | Cerebral hemodynamic response to acute hyperoxia in awake mice. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Tajima, Yosuke
× Tajima, Yosuke× Takuwa, Hiroyuki× Nishino, Asuka× Matsuura, Tetsuya× Kawaguchi, Hiroshi× Ikoma, Yoko× Taniguchi, Junko× Seki, Chie× Masamoto, Kazuto× Kanno, Iwao× Saeki, Naokatsu× Ito, Hiroshi× 田島 洋佑× 田桑 弘之× 西野 明日香× 松浦 哲也× 川口 拓之× 生駒 洋子× 谷口 順子× 関 千江× 正本 和人× 菅野 巖× 伊藤 浩 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Cerebral hemodynamic response to acute hyperoxia was investigated in awake mice. Using laser-Doppler flowmetry (LDF), baseline cerebral blood flow (CBF) and the cerebrovascular responses to whisker stimulation were measured in awake mice during normoxia and hyperoxia. Using two-photon laser scanning microscopy (TPLSM), the changes in cortical microvasculature were measured during normoxia and hyperoxia. During hyperoxia (PaO2=482.3±19.7mmHg), baseline CBF was 6.8% lower than normoxia (PaO2=97.3±6.0mmHg). The degree of increase in CBF evoked by whisker stimulation was greater during hyperoxia (18.1±5.0%) than normoxia (13.1±3.5%) (P<0.05). TPLSM imaging of the somatosensory cortex showed vasconstriction in arterioles and capillaries during hyperoxia. Since the effective diffusivity for oxygen in the capillary bed might decrease by hyperoxia due to a decrease in capillary blood volume according to Hyder׳s model, an increase in the cerebral metabolic rate of oxygen utilization by neural activation during hyperoxia might need a greater increase in CBF as compared with normoxia. The hemodynamic response to neural activation could be modified by acute hyperoxia due to modification of the relation between changes in CBF and oxygen consumption by neural activation. | |||||
| 書誌情報 |
Brain research 巻 1557, p. 155-63, 発行日 2014-01 |
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| 出版者 | ||||||
| 出版者 | ELSEVIER | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0006-8993 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 24508909 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.brainres.2014.01.053 | |||||
