WEKO3
アイテム
Viral protein-coating of magnetic nanoparticles using simian virus 40 VP1.
https://repo.qst.go.jp/records/46789
https://repo.qst.go.jp/records/467893d17e85a-63fb-4dd7-ab05-8ec84dc223fb
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-07-23 | |||||
| タイトル | ||||||
| タイトル | Viral protein-coating of magnetic nanoparticles using simian virus 40 VP1. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Enomoto, Teruya
× Enomoto, Teruya× Yamaguchi, Yuki× HATAKEYAMA, Mamoru× Saito, Shigeyoshi× Aoki, Ichio× Handa, Hiroshi× et.al× 畠山 士× 齋藤 茂芳× 青木 伊知男 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Artificial beads including magnetite and fluorescence particles are useful to visualize pathologic tissue, such as cancers, from harmless types by magnetic resonance imaging (MRI) or fluorescence imaging. Desirable properties of diagnostic materials include high dispersion in body fluids, and the ability to target specific tissues. Here we report on the development of novel magnetic nanoparticles (MNPs) intended for use as diagnosis and therapy that are coated with viral capsid protein VP1-pentamers of simian virus 40, which are monodispersive in body fluid by conjugating epidermal growth factor (EGF) to VP1. Critically, the coating of MNPs with VP1 facilitated stable dispersion of the MNPs in body fluids. In addition, EGF was conjugated to VP1 coating on MNPs (VP1-MNPs). EGF-conjugated VP1-MNPs were successfully used to target EGF receptor-expressing tumor cells in vitro. Thus, using viral capsid protein VP1 as a coating material would be useful for medical diagnosis and therapy. | |||||
| 書誌情報 |
Journal of Biotechnology 巻 167, 号 1, p. 8-15, 発行日 2013-06 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0168-1656 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.jbiotec.2013.06.005. | |||||
