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Effects of shielding on the induction of 53BP1 foci and micronuclei after Fe ion exposures.
https://repo.qst.go.jp/records/46773
https://repo.qst.go.jp/records/46773c2816592-afde-4e5c-a926-cbc10e28e180
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-07-16 | |||||
| タイトル | ||||||
| タイトル | Effects of shielding on the induction of 53BP1 foci and micronuclei after Fe ion exposures. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hu, Wentao
× Hu, Wentao× Pei, Hailong× Li, He× Ding, Nan× Wang, Jufang× He, Jinpeng× Furusawa, Yoshiya× Hirayama, Ryoichi× Matsumoto, Yoshitaka× Liu, Cuihua× Li, Yinghui× Kawata, Tetsuya× Zhou, Guangming× 古澤 佳也× 平山 亮一× 松本 孔貴× 劉 翠華 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | High atomic number and high-energy (HZE) particles in deep space are of low abundance but substantially contribute to the biological effects of space radiation. Shielding is so far the most effective way to partially protect astronauts from these highly penetrating particles. However, simulated calculations and measurements have predicted that secondary particles resulting from the shielding of cosmic rays produce a significant fraction of the total dose and dose equivalent. In this study, we investigated the biological effects of secondary radiation with two cell types, and with cells exposed in different phases of the cell cycle, by comparing the biological effects of a 200 MeV/u iron beam with a shielded beam in which the energy of the iron ion beam was decreased from 500 MeV/u to 200 MeV/u with PMMA, polyethylene (PE), or aluminum. We found that beam shielding resulted in increased induction of 53BP1 foci and micronuclei in a cell-type-dependent manner compared with the unshielded 200 MeV/u Fe ion beam. These findings provide experimental proof that the biological effects of secondary particles resulting from the interaction between HZE particles and shielding materials should be considered in shielding design. | |||||
| 書誌情報 |
Journal of radiation research 巻 55, 号 1, p. 10-16, 発行日 2013-05 |
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| 出版者 | ||||||
| 出版者 | Oxford University Press | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1349-9157 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 23728321 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1093/jrr/rrt078 | |||||
