WEKO3
アイテム
Exposure to gamma-rays at the telogen phase of the hair cycle inhibits hair follicle regeneration at the anagen phase in mice
https://repo.qst.go.jp/records/46759
https://repo.qst.go.jp/records/46759e5bbf54b-41a6-4d84-9a30-452fa2a5c9dc
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-05-13 | |||||
| タイトル | ||||||
| タイトル | Exposure to gamma-rays at the telogen phase of the hair cycle inhibits hair follicle regeneration at the anagen phase in mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kimihiko, Sugaya
× Kimihiko, Sugaya× Tomohisa, Hirobe× 菅谷 公彦× 廣部 知久 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: The effects of ionizing radiations on somatic stem cells largely remain to be studied. Hair follicles are self-renewing structures that reconstitute themselves throughout the hair cycle, which is comprised of the following phases: anagen (growth), catagen (regression) and telogen (resting), suggesting the presence of their own stem cells. Materials & methods: The whole bodies of C57BL/10JHir mice in the 1st telogen phase were irradiated with γ-rays. Mice were examined for effects on hair follicles, including their number, morphology and pigmentation in the 2nd anagen phase. Results: Decreased hair follicle density and induction of curved hair follicles were observed in the dermal skin of irradiated mice. In addition to these keratinocyte-derived anomalies, melanocyte-derived anomalies including white hair and hypopigmented hair bulbs were found. The decrease in hair follicle density and the increase in the frequency of hypopigmented hair bulbs were dependent on the dose of γ-rays. Conclusions: These results suggest that γ-rays damage stem cells and progenitors for keratinocytes and melanocytes, thereby affecting the structure and character of regenerated hair follicles. The density of hair follicles and pigment production in hair bulbs are established as criteria for the effects of γ-rays on the hair cycle. |
|||||
| 書誌情報 |
International Journal of Radiation Biology 巻 90, 号 2, p. 127-132, 発行日 2013-11 |
|||||
| 出版者 | ||||||
| 出版者 | informa healthcare | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0955-3002 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 24266431 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3109/09553002.2014.868618 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://informahealthcare.com/toc/rab/90/2 | |||||
| 関連名称 | http://informahealthcare.com/toc/rab/90/2 | |||||
