WEKO3
アイテム
Molecular Imaging of Aquaglycero-Aquaporins: Its Potential for Cancer Characterization
https://repo.qst.go.jp/records/46731
https://repo.qst.go.jp/records/4673142f74038-7b55-4f0a-bf20-6621a8069511
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-03-04 | |||||
| タイトル | ||||||
| タイトル | Molecular Imaging of Aquaglycero-Aquaporins: Its Potential for Cancer Characterization | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Saito, Yuriko
× Saito, Yuriko× Furukawa, Takako× Obata, Takayuki× Saga, Tsuneo× 齋藤 有里子× 古川 高子× 小畠 隆行× 佐賀 恒夫 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Aquaglycero-aquaporins (agAQPs) are one of the water channel proteins located in the cell membrane that transport not only water but also some small solutes such as glycerol. Since agAQPs are involved in cancer proliferation and malignancy, it might be possible to utilize them as new targets for cancer molecular imaging. In this study, we investigated whether agAQPs can be specifically targeted by using [14C]-labeled glycerol ([14C]glycerol), which passes through agAQPs. In the in vitro experiments, comparing the cancer cell lines with different expression levels of AQP3 and AQP9, major agAQPs known to be expressed in cancers, and examining the effect of their inhibitors on these cells, the expression of AQP3 and AQP9 in cell lines was shown to be closely related to [14C]glycerol uptake. When [14C]glycerol was injected into tumor-bearing mice, Spearman's rank coefficient analysis revealed that radioactivity levels in tumor and in plasma were mutually correlated only in tumors expressing agAQPs at a high level. These results indicate the possibility of using agAQPs as new targets to characterize cancer using radiolabeled glycerol as a molecular probe. | |||||
| 書誌情報 |
Biological & Pharmaceutical Bulletin 巻 36, 号 8, p. 1292-1298, 発行日 2013-08 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0918-6158 | |||||
