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A microdosimetric-kinetic model for cell killing by protracted continuous irradiation including dependence on LET I: Repair in cultured mammalian cells
https://repo.qst.go.jp/records/46691
https://repo.qst.go.jp/records/46691dac3309f-76ab-4332-bcb5-5242399042b6
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-01-14 | |||||
| タイトル | ||||||
| タイトル | A microdosimetric-kinetic model for cell killing by protracted continuous irradiation including dependence on LET I: Repair in cultured mammalian cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
B, Hawkins Roland
× B, Hawkins Roland× Inaniwa, Taku× 稲庭 拓 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Relations based on the microdosimetric-kinetic (MK) model are presented that describe killing of mammalian cells by protracted continuous exposure to ionizing radiation of varying linear energy transfer quality (LET) at constant dose rate. The consequences of continuous irradiation exposure actually consisting of a discontinuous sequence of events corresponding to passage of each high-energy particle through or near the cell are incorporated into the model. The derived relations are applied to protracted irradiation experiments of Amdur and Bedford to determine the rate of repair of potentially lethal lesions. It is found that as the dose rate becomes less than about 5 Gy per hour the repair rate decreases significantly with decreasing dose rate. This suggests that repair function in these cells is induced and maintained in response to the intensity of irradiation. Clinical and radiation protection implications of this finding are noted. |
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| 書誌情報 |
Radiation Research 巻 180, 号 6, p. 584-594, 発行日 2013-11 |
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| 出版者 | ||||||
| 出版者 | Allen Press | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1667/RR13257.1 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.rrjournal.org/toc/rare/180/6 | |||||
| 関連名称 | http://www.rrjournal.org/toc/rare/180/6 | |||||
