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The contribution of indirect action on\ncell killing can be estimated from the maximum degree of\nprotection by dimethylsulfoxide, which suppresses indirect\naction by quenching OH radicals without affecting the direct\naction of X rays on cell killing. The contributions of indirect\naction on cell killing of CHO cells were 76% and 50% under\noxic and hypoxic conditions, respectively, and those for AA8\ncells were 85% and 47%, respectively. Therefore, the indirect\naction on cell killing was enhanced by oxygen during X\nirradiation in both cell lines tested. Oxygen enhancement\nratios (OERs) at the 10% survival level (D10 or LD90) for CHO\nand AA8 cells were 2.68 6 0.15 and 2.76 6 0.08, respectively.\nOERs were evaluated separately for indirect and direct\nactions, which gave the values of 3.75 and 2.01 for CHO, and\n4.11 and 1.32 for AA8 cells, respectively. Thus the generally\naccepted OER value of 3 is best understood as the average\nof the OER values for both indirect and direct actions. These\nresults imply that both indirect and direct actions on cell\nkilling require oxygen for the majority of lethal DNA\ndamage, however, oxygen plays a larger role in indirect than\nfor direct effects. Conversely, the lethal damage induced by\nthe direct action of X rays are less affected by oxygen\nconcentration.", "subitem_description_type": "Abstract"}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0033-7587", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Hirayama, Ryoichi"}], "nameIdentifiers": [{"nameIdentifier": "905127", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ito, Atsushi"}], "nameIdentifiers": [{"nameIdentifier": "905128", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Noguchi, Miho"}], "nameIdentifiers": [{"nameIdentifier": "905129", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsumoto, Yoshitaka"}], "nameIdentifiers": [{"nameIdentifier": "905130", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Uzawa, Akiko"}], "nameIdentifiers": [{"nameIdentifier": "905131", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kobashi, Gen"}], "nameIdentifiers": [{"nameIdentifier": "905132", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okayasu, Ryuichi"}], "nameIdentifiers": [{"nameIdentifier": "905133", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Furusawa, Yoshiya"}], "nameIdentifiers": [{"nameIdentifier": "905134", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hirayama, Ryoichi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "905135", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ito, Atsushi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "905136", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsumoto, Yoshitaka", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "905137", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Uzawa, Akiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "905138", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kobashi, Gen", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "905139", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okayasu, Ryuichi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "905140", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Furusawa, Yoshiya", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "905141", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "OH Radicals from the Indirect Actions of X-Rays Induce Cell Lethality and Mediate the Majority of the Oxygen Enhancement Effect", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "OH Radicals from the Indirect Actions of X-Rays Induce Cell Lethality and Mediate the Majority of the Oxygen Enhancement Effect"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/46685", "pubdate": {"attribute_name": "公開日", "attribute_value": "2013-11-16"}, "publish_date": "2013-11-16", "publish_status": "0", "recid": "46685", "relation": {}, "relation_version_is_last": true, "title": ["OH Radicals from the Indirect Actions of X-Rays Induce Cell Lethality and Mediate the Majority of the Oxygen Enhancement Effect"], "weko_shared_id": -1}
OH Radicals from the Indirect Actions of X-Rays Induce Cell Lethality and Mediate the Majority of the Oxygen Enhancement Effect
https://repo.qst.go.jp/records/46685
https://repo.qst.go.jp/records/46685e2d41d7d-8042-4a86-94b2-6fc5b0e6a593
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-11-16 | |||||
タイトル | ||||||
タイトル | OH Radicals from the Indirect Actions of X-Rays Induce Cell Lethality and Mediate the Majority of the Oxygen Enhancement Effect | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Hirayama, Ryoichi
× Hirayama, Ryoichi× Ito, Atsushi× Noguchi, Miho× Matsumoto, Yoshitaka× Uzawa, Akiko× Kobashi, Gen× Okayasu, Ryuichi× Furusawa, Yoshiya× Hirayama, Ryoichi× Ito, Atsushi× Matsumoto, Yoshitaka× Uzawa, Akiko× Kobashi, Gen× Okayasu, Ryuichi× Furusawa, Yoshiya |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We examined OH radical-mediated indirect actions from X irradiation on cell killing in wild-type Chinese hamster ovary cell lines (CHO and AA8) under oxic and hypoxic conditions, and compared the contribution of direct and indirect actions under both conditions. The contribution of indirect action on cell killing can be estimated from the maximum degree of protection by dimethylsulfoxide, which suppresses indirect action by quenching OH radicals without affecting the direct action of X rays on cell killing. The contributions of indirect action on cell killing of CHO cells were 76% and 50% under oxic and hypoxic conditions, respectively, and those for AA8 cells were 85% and 47%, respectively. Therefore, the indirect action on cell killing was enhanced by oxygen during X irradiation in both cell lines tested. Oxygen enhancement ratios (OERs) at the 10% survival level (D10 or LD90) for CHO and AA8 cells were 2.68 6 0.15 and 2.76 6 0.08, respectively. OERs were evaluated separately for indirect and direct actions, which gave the values of 3.75 and 2.01 for CHO, and 4.11 and 1.32 for AA8 cells, respectively. Thus the generally accepted OER value of 3 is best understood as the average of the OER values for both indirect and direct actions. These results imply that both indirect and direct actions on cell killing require oxygen for the majority of lethal DNA damage, however, oxygen plays a larger role in indirect than for direct effects. Conversely, the lethal damage induced by the direct action of X rays are less affected by oxygen concentration. |
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書誌情報 |
Radiation Research 巻 180, 号 5, p. 514-523, 発行日 2013-11 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0033-7587 |