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Uranium dynamics and developmental sensitivity in rat kidney
https://repo.qst.go.jp/records/46681
https://repo.qst.go.jp/records/4668102692336-5b4b-499e-9cc9-493870c7360a
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-12-12 | |||||
| タイトル | ||||||
| タイトル | Uranium dynamics and developmental sensitivity in rat kidney | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Homma-Takeda, Shino
× Homma-Takeda, Shino× Kokubo, Toshiaki× Terada, Yasuko× Suzuki, Kyoko× Ueno, Shunji× Hayao, Tatsuo× Inoue, Tatsuya× Kitahara, Keisuke× Blyth, Benjamin× Nishimura, Mayumi× Shimada, Yoshiya× 武田 志乃× 小久保 年章× 上野 俊治× 早尾 辰雄× 井上 達也× Ｂｌｙｔｈ Ｂｅｎｊａｍｉｎ× 西村 まゆみ× 島田 義也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Renal toxicity is the principal health concern following uranium exposure. Children are particularly vulnerable to uranium exposure; with contact with depleted uranium in war zones or groundwater contamination the most likely exposure scenarios. To investigate renal sensitivity to uranium exposure during development, we examined uranium distribution and uranium-induced apoptosis in the kidneys of neonate (7-day-old), prepubertal (25-day-old), and adult (70-day-old) male Wistar rats. Mean renal uranium concentrations increased with both age-at-exposure and exposure level following subcutaneous administration of uranium acetate (UA) (0.1–2 mg/kg body weight). Although less of the injected uranium was deposited in the kidneys of the two younger rat groups, the proportion of the peak uranium content remaining in the kidneys after two weeks declined with age-at-exposure, suggesting reduced clearance in younger animals. In situ high-energy synchrotron radiation X-ray fluorescence analysis revealed site-specific accumulation of uranium in the S3 segment of the proximal tubules, distributed in the inner cortex and outer stripe of the outer medulla. Apoptosis and cell loss in the proximal tubules increased with age-at-exposure to 0.5 mg/kg UA. Surprisingly, prepubertal rats were uniquely sensitive to uranium-induced lethality from the higher exposure levels. Observations of increased apoptosis in generating/re-generating tubules particularly in prepubertal rats could help to explain their high mortality rate. Together, our findings suggest that age-at-exposure and exposure level are important parameters for uranium toxicity; uranium tends to persist in developing kidneys after low-level exposures, although renal toxicity is more pronounced in adults. | |||||
| 書誌情報 |
Journal of Applied Toxicology 巻 33, 号 7, p. 685-694, 発行日 2013-07 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0260-437X | |||||
