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Upregulated expression of FGF13/FHF2 mediates resistance to platinum drugs in cervical cancer cells
https://repo.qst.go.jp/records/46677
https://repo.qst.go.jp/records/466773450b775-5e88-4f0b-aa10-69381675cb9c
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-12-12 | |||||
| タイトル | ||||||
| タイトル | Upregulated expression of FGF13/FHF2 mediates resistance to platinum drugs in cervical cancer cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Okada, Tomoko
× Okada, Tomoko× Murata, Kazuhiro× Hirose, Ryoma× Matsuda, Chie× Komatsu, Tsunehiko× Ikekita, Masahiko× Nakawatari, Miyako× Nakayama, Fumiaki× Wakatsuki, Masaru× Ohno, Tatsuya× Kato, Shingo× Imai, Takashi× Imamura, Toru× 松田 知栄× 中渡 美也子× 中山 文明× 若月 優× 加藤 眞吾× 今井 高志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Cancer cells often develop drug resistance. In cisplatin-resistant HeLa cisRcells, fibroblast growth factor 13 (FGF13/FHF2) gene and protein expression was strongly upregulated, and intracellular platinum concentrations were kept low. When the FGF13 expression was suppressed, both the cells' resistance to platinum drugs and their ability to keep intracellular platinum low were abolished. Overexpression of FGF13 in parent cells led to greater resistance to cisplatin and reductions in the intracellular platinum concentration. These cisplatin-resistant cells also showed increased resistance to copper. In preoperative cervical cancer biopsy samples from poor prognoses patients after cisplatin chemoradiotherapy, FGF13-positive cells were detected more abundantly than in the biopsy samples from patients with good prognoses. These results suggest that FGF13 plays a pivotal role in mediating resistance to platinum drugs, possibly via a mechanism shared by platinum and copper. Our results point to FGF13 as a novel target and useful prognostic guide for cancer therapy. | |||||
| 書誌情報 |
Scientific Reports (Online Only URL:http://www.nature.com/srep/index.html) 巻 3, 号 2899, 発行日 2013-10 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2045-2322 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/srep02899 | |||||
