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Comparison of the binding characteristics of [(18)F]THK-523 and other amyloid imaging tracers to Alzheimer's disease pathology.
https://repo.qst.go.jp/records/46627
https://repo.qst.go.jp/records/4662768911267-b739-4782-a492-f2ed2aeca6f5
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-11-26 | |||||
| タイトル | ||||||
| タイトル | Comparison of the binding characteristics of [(18)F]THK-523 and other amyloid imaging tracers to Alzheimer's disease pathology. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Harada, Ryuichi
× Harada, Ryuichi× Okamura, Nobuyuki× Furumoto, Shozo× Tago, Tetsuro× Maruyama, Masahiro× Higuchi, Makoto× et.al× 原田 龍一× 岡村 信行× 古本 祥三× 多胡 哲郎× 丸山 将浩× 樋口 真人 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose Extensive deposition of senile plaques and neurofibrillary tangles in the brain is a pathological hallmark of Alzheimer disease (AD). Although several PET imaging agents have been developed for in vivo detection of senile plaques, no PET probe is currently available for selective detection of neurofibrillary tangles in the living human brain. Recently, [18F]THK-523 was developed as a potential in vivo imaging probe for tau pathology. The purpose of this study was to compare the binding properties of [18F]THK-523 and other amyloid imaging agents, including PiB, BF-227 and FDDNP, to synthetic protein fibrils and human brain tissue. \nMethods In vitro radioligand binding assays were conducted using synthetic amyloid beta42 and K18 deltaK280-tau fibrils. Nonspecific binding was determined by the addition of unlabelled compounds at a concentration of 2 micro M. To examine radioligand binding to neuropathological lesions, in vitro autoradiography was conducted using sections of AD brain. \nResults [18F]THK-523 showed higher affinity for tau fibrils than for Abeta fibrils, whereas the other probes showed a higher affinity for Abeta fibrils. The autoradiographic analysis indicated that [18F]THK-523 accumulated in the regions containing a high density of tau protein deposits. Conversely, PiB and BF-227 accumulated in the regions containing a high density of Abeta plaques. \nConclusion These findings suggest that the unique binding profile of [18F]THK-523 can be used to identify tau deposits in AD brain. |
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| 書誌情報 |
European Journal of Nuclear Medicine and Molecular Imaging 巻 40, 号 1, p. 125-132, 発行日 2012-10 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1619-7070 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s00259-012-2261-2. | |||||
