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Synthesis and evaluation of [11C]MMPIP as a potential radioligand for imaging of metabotropic glutamate 7 receptor in the brain
https://repo.qst.go.jp/records/46601
https://repo.qst.go.jp/records/46601c1895254-0e3a-457e-98eb-8a5c7ca42a97
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-10-09 | |||||
タイトル | ||||||
タイトル | Synthesis and evaluation of [11C]MMPIP as a potential radioligand for imaging of metabotropic glutamate 7 receptor in the brain | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Yamasaki, Tomoteru
× Yamasaki, Tomoteru× Kumata, Katsushi× Yui, Joji× Fujinaga, Masayuki× Furutsuka, Kenji× Hatori, Akiko× Xie, Lin× Ogawa, Masanao× Nengaki, Nobuki× Kawamura, Kazunori× Zhang, Ming-Rong× 山崎 友照× 熊田 勝志× 由井 譲二× 藤永 雅之× 古塚 賢士× 羽鳥 晶子× 謝 琳× 小川 政直× 念垣 信樹× 河村 和紀× 張 明栄 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: Metabotropic glutamate 7 (mGlu7) receptor is a crucial target protein for the development of pharmaceuticals against central nervous system disorders. In the present study, we synthesized [11C]MMPIP, a putative radioligand for mGlu7 (binding constant KB = 30 nM), and evaluated its potential for imaging of mGlu7 via in vitro and in vivo technique |
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書誌情報 |
EJNMMI Research (Online Only URL: http://link.springer.com/journal/13550) 巻 3, 号 54, 発行日 2013-08 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2191-219X | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1186/2191-219x-3-54 |